New insights into the mechanisms of acute kidney injury in the intensive care unit

Abstract Acute kidney injury is a frequent complication in the intensive care unit that is associated with increased mortality and morbidity. Traditional models consider reductions of global renal blood flow as the cause of acute kidney injury. However, a complex interplay between ischemia-reperfusi...

Full description

Saved in:
Bibliographic Details
Published in:Journal of clinical anesthesia 2015-03, Vol.27 (2), p.175-180
Main Authors: Glodowski, Seth D., MD, Wagener, Gebhard, MD
Format: Article
Language:English
Subjects:
Acute Kidney Injury - chemically induced
Acute Kidney Injury - etiology
Acute Kidney Injury - physiopathology
Anesthesia & Perioperative Care
Fluids
Heart surgery
Hemodynamics - physiology
Humans
Inflammation - complications
Intensive care
Intensive Care Units
Ischemia
Ischemia reperfusion injury
Kidney - physiopathology
Kidney diseases
Ligands
Mortality
Nonsteroidal anti-inflammatory drugs
Pain Medicine
Postoperative period
Renal autoregulation
Renal blood flow
Renal Circulation - physiology
Reperfusion Injury - complications
RIFLE criteria
Sepsis
Sepsis - complications
Septic AKI
Urine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Acute kidney injury is a frequent complication in the intensive care unit that is associated with increased mortality and morbidity. Traditional models consider reductions of global renal blood flow as the cause of acute kidney injury. However, a complex interplay between ischemia-reperfusion injury and inflammation may lead to intrarenal hypoperfusion and acute kidney injury. The role of changes of global renal blood flow as a cause for acute kidney injury remains controversial, especially in sepsis-induced acute kidney injury.
ISSN:0952-8180
1873-4529
DOI:10.1016/j.jclinane.2014.09.011