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Variability of fractional flow reserve according to the methods of hyperemia induction
Objectives We performed this study to evaluate the variability of fractional flow reserve (FFR) values which were measured from various methods of hyperemia induction. Background Concerns have been raised regarding the variability of FFR due to different routes for hyperemic agent administration and...
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Published in: | Catheterization and cardiovascular interventions 2015-05, Vol.85 (6), p.970-976 |
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Main Authors: | , , , , , , , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Objectives
We performed this study to evaluate the variability of fractional flow reserve (FFR) values which were measured from various methods of hyperemia induction.
Background
Concerns have been raised regarding the variability of FFR due to different routes for hyperemic agent administration and different hyperemic agents targeting different receptors to induce maximal hyperemia.
Methods
A total of 656 intermediate coronary lesions from 628 patients with coronary artery disease were analyzed. Among them, 238 lesions underwent FFR measurement with hyperemia induced by both intravenous (IV) and intracoronary (IC) adenosine administration, 318 by IV adenosine/adenosine triphosphate (ATP) and IC nicorandil injection, and 100 by IV adenosine and regadenoson infusion.
Results
Excellent correlation and close classification agreement (FFR ≤ 0.80) were observed between IV vs. IC adenosine (r = 0.980, CA = 92.9%, Cohen's Kappa = 0.887, P |
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ISSN: | 1522-1946 1522-726X |
DOI: | 10.1002/ccd.25752 |