Evolution of vertebrates as viewed from the crest

The origin of vertebrates was accompanied by the advent of a novel cell type: the neural crest. Emerging from the central nervous system, these cells migrate to diverse locations and differentiate into numerous derivatives. By coupling morphological and gene regulatory information from vertebrates a...

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Bibliographic Details
Published in:Nature (London) 2015-04, Vol.520 (7548), p.474-482
Main Authors: Green, Stephen A., Simoes-Costa, Marcos, Bronner, Marianne E.
Format: Article
Language:English
Subjects:
631/136
Analysis
Animals
Biological Evolution
Cell Proliferation
Central nervous system
Chordata, Nonvertebrate - cytology
Chordata, Nonvertebrate - embryology
Evolution
Evolutionary biology
Gene Duplication - genetics
Gene Expression Regulation, Developmental
Gene Regulatory Networks
Genetic research
Humanities and Social Sciences
Morphology
multidisciplinary
Nervous system
Neural crest
Neural Crest - cytology
Neural Crest - metabolism
Physiological aspects
review-article
Science
Stem cells
Stem Cells - cytology
Topology
Vertebrates
Vertebrates - anatomy & histology
Vertebrates - embryology
Vertebrates - genetics
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Summary:The origin of vertebrates was accompanied by the advent of a novel cell type: the neural crest. Emerging from the central nervous system, these cells migrate to diverse locations and differentiate into numerous derivatives. By coupling morphological and gene regulatory information from vertebrates and other chordates, we describe how addition of the neural-crest-specification program may have enabled cells at the neural plate border to acquire multipotency and migratory ability. Analysis of the topology of the neural crest gene regulatory network can serve as a useful template for understanding vertebrate evolution, including elaboration of neural crest derivatives.
ISSN:0028-0836
1476-4687
DOI:10.1038/nature14436