Mast cell infiltrates in vulvodynia represent secondary and idiopathic mast cell hyperplasias

Mast cell infiltrates in tissues of vulvodynia are common, but they have not been characterized for criteria of neoplastic mast cell disease or correlated with patient's concomitant diseases associated with increased mast cells. Formalin‐fixed specimens of 35 patients with vulvodynia were evalu...

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Published in:APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 2015-05, Vol.123 (5), p.452-456
Main Authors: Regauer, Sigrid, Eberz, Barbara, Beham-Schmid, Christine
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Allergies
Antigens, CD - metabolism
c-kit mutation D816V
CD25 expression
Cytokines
Female
Histamine
Humans
Hyperplasia
mast cell activation
mast cell hyperplasia
Mast Cells - immunology
Mast Cells - pathology
Middle Aged
Mutation
Proto-Oncogene Proteins c-kit - genetics
spindled mast cells
Tryptases - blood
Vulvar pain
Vulvodynia - enzymology
Vulvodynia - immunology
Vulvodynia - pathology
Young Adult
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Summary:Mast cell infiltrates in tissues of vulvodynia are common, but they have not been characterized for criteria of neoplastic mast cell disease or correlated with patient's concomitant diseases associated with increased mast cells. Formalin‐fixed specimens of 35 patients with vulvodynia were evaluated immunohistochemically with antibodies to CD 3,4,8,20,117c and human mast cell tryptase, and for WHO‐criteria of neoplastic mastocytosis (>25% spindled mast cell, CD25 expression, point mutations of the c‐kit gene (D816V), and chronically elevated serum tryptase levels). Only 20/35 specimens showed a T‐lymphocyte dominant inflammatory infiltrate on HE‐stained sections, but all showed mast cells. 4/35 biopsies showed 60 mast cells/mm2 (average 80/mm2). Control tissue contained typically 40 mast cells/mm2 were classified as a secondary mast cell disorder reflecting an activated immune system in 75% of vulvodynia patients. Patients with increased mast cells may benefit from medical therapy targeting mast cells.
ISSN:0903-4641
1600-0463
DOI:10.1111/apm.12372