Signal transducers and activators of transcription 3-induced metastatic potential in gastric cancer cells is enhanced by glycogen synthase kinase-3β

The transcription factor signal transducers and activators of transcription 3 (STAT3) can promote cancer metastasis, but its underlying regulatory mechanisms in gastric cancer cell invasiveness still remain obscure. We investigated the relationship between STAT3 and glycogen synthase kinase‐3β (GSK‐...

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Published in:APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 2015-05, Vol.123 (5), p.373-382
Main Authors: Yoon, Jiyeon, Ko, Young San, Cho, Sung Jin, Park, Jinju, Choi, Young Sun, Choi, Yiseul, Pyo, Jung-Soo, Ye, Sang-Kyu, Youn, Hong-Duk, Lee, Jae-Seon, Chang, Mee Soo, Kim, Min A, Lee, Byung Lan
Format: Article
Language:English
Subjects:
Amino Acid Substitution
Biomarkers, Tumor - metabolism
Cell Line, Tumor
Cell Movement - physiology
Epithelial-Mesenchymal Transition - physiology
gastric cancer
Gene Knockdown Techniques
Glycogen Synthase Kinase 3 - antagonists & inhibitors
Glycogen Synthase Kinase 3 - genetics
Glycogen Synthase Kinase 3 - metabolism
Glycogen Synthase Kinase 3 beta
GSK-3β
Humans
Immunohistochemistry
invasion
migration
Mutant Proteins - genetics
Mutant Proteins - metabolism
Neoplasm Invasiveness - physiopathology
RNA, Small Interfering - genetics
Signal Transduction
STAT3
STAT3 Transcription Factor - antagonists & inhibitors
STAT3 Transcription Factor - genetics
STAT3 Transcription Factor - metabolism
Stomach Neoplasms - metabolism
Stomach Neoplasms - pathology
Stomach Neoplasms - secondary
Thiazoles - pharmacology
Tyrphostins - pharmacology
Urea - analogs & derivatives
Urea - pharmacology
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Summary:The transcription factor signal transducers and activators of transcription 3 (STAT3) can promote cancer metastasis, but its underlying regulatory mechanisms in gastric cancer cell invasiveness still remain obscure. We investigated the relationship between STAT3 and glycogen synthase kinase‐3β (GSK‐3β) and its significance in metastatic potential in gastric cancer cells. Immunohistochemical tissue array analysis of 267 human gastric carcinoma specimens showed that the expressions of active forms of STAT3 (pSTAT3) and GSK‐3β (pGSK‐3β) were found in 68 (25%) and 124 (46%) of 267 gastric cancer cases, respectively, showing a positive correlation (p 
ISSN:0903-4641
1600-0463
DOI:10.1111/apm.12370