Glial fibrillary acidic protein: The component of iintermediate filaments in the vertebrate brain astrocytes

Glial fibrillary acidic protein (GFAP) refers to the type III intermediate filament proteins and is an essential component of the cytoskeleton in astrocytes of all vertebrates. This review presents current data on the molecular organization of GFAP in a comparative aspect. The results of most releva...

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Bibliographic Details
Published in:Journal of evolutionary biochemistry and physiology 2015, Vol.51 (1), p.1-10
Main Authors: Sukhorukova, E. G., Korzhevskii, D. E., Alekseeva, O. S.
Format: Article
Language:English
Subjects:
Animal Physiology
Biochemistry
Biomedical and Life Sciences
Brain
Cytoskeleton
Evolutionary Biology
Life Sciences
Neurobiology
Neurological disorders
Proteins
Reviews
Vertebrates
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Summary:Glial fibrillary acidic protein (GFAP) refers to the type III intermediate filament proteins and is an essential component of the cytoskeleton in astrocytes of all vertebrates. This review presents current data on the molecular organization of GFAP in a comparative aspect. The results of most relevant studies using immunocytochemical labeling of the protein are summarized. The data on the changes in expression of GFAP in Alexander disease caused by the primary pathology of astrocytes are presented.
ISSN:0022-0930
1608-3202
DOI:10.1134/S0022093015010019