Pharmacokinetics of gadobenate dimeglumine in children 2 to 5 years of age undergoing MRI of the central nervous system

Purpose To determine the pharmacokinetic profile of gadobenate dimeglumine in children aged between 2 and 5 years. Materials and Methods Fifteen children scheduled to undergo contrast‐enhanced MRI for suspected disease of the central nervous system received a single intravenous injection of 0.1 mmol...

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Bibliographic Details
Published in:Journal of magnetic resonance imaging 2015-04, Vol.41 (4), p.1096-1103
Main Authors: Pirovano, Gianpaolo, Kirchin, Miles A., Lorusso, Vito, Patel, Rutu, Shen, Ningyan
Format: Article
Language:English
Subjects:
Aging - metabolism
Aging - pathology
Brain - anatomy & histology
Brain - metabolism
Child, Preschool
children
Contrast Media - pharmacokinetics
Female
gadobenate dimeglumine
Humans
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Meglumine - analogs & derivatives
Meglumine - pharmacokinetics
Metabolic Clearance Rate
Organometallic Compounds - pharmacokinetics
pharmacokinetics
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Summary:Purpose To determine the pharmacokinetic profile of gadobenate dimeglumine in children aged between 2 and 5 years. Materials and Methods Fifteen children scheduled to undergo contrast‐enhanced MRI for suspected disease of the central nervous system received a single intravenous injection of 0.1 mmol/kg gadobenate dimeglumine. Children were stratified into three age groups: 2 to
ISSN:1053-1807
1522-2586
DOI:10.1002/jmri.24653