Patterns of Hepatitis C Virus RNA Levels during Acute Infection: The InC3 Study: e0122232

Background Understanding the patterns of HCV RNA levels during acute hepatitis C virus (HCV) infection provides insights into immunopathogenesis and is important for vaccine design. This study evaluated patterns of HCV RNA levels and associated factors among individuals with acute infection. Methods...

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Published in:PloS one 2015-04, Vol.10 (4)
Main Authors: Hajarizadeh, Behzad, Grady, Bart, Page, Kimberly, Kim, Arthur Y, McGovern, Barbara H, Cox, Andrea L, Rice, Thomas M, Sacks-Davis, Rachel, Bruneau, Julie, Morris, Meghan
Format: Article
Language:English
Subjects:
Hepatitis C virus
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Summary:Background Understanding the patterns of HCV RNA levels during acute hepatitis C virus (HCV) infection provides insights into immunopathogenesis and is important for vaccine design. This study evaluated patterns of HCV RNA levels and associated factors among individuals with acute infection. Methods Data were from an international collaboration of nine prospective cohorts of acute HCV (InC3 Study). Participants with well-characterized acute HCV infection (detected within three months post-infection and interval between the peak and subsequent HCV RNA levels less than or equal to 120 days) were categorised by a priori-defined patterns of HCV RNA levels: i) spontaneous clearance, ii) partial viral control with persistence ( greater than or equal to 1 log IU/mL decline in HCV RNA levels following peak) and iii) viral plateau with persistence (increase or
ISSN:1932-6203
DOI:10.1371/journal.pone.0122232