Global dynamic analysis of a H7N9 avian-human influenza model in an outbreak region

• Published in: Journal of theoretical biology 2015-02, Vol.367, p.180-188
• Main Authors: Chen, Yongxue, Wen, Yongxian
• Format: Article
• Language: English
• Subjects: Animals; Avian influenza virus; China - epidemiology; Computer Simulation; Disease Models, Animal; Disease Outbreaks - statistics & numerical data; Humans; Influenza A Virus, H7N9 Subtype - physiology; Influenza in Birds - epidemiology; Influenza in Birds - virology; Influenza, Human - epidemiology; Influenza, Human - virology; Internationality; Models, Biological; Population Density; Poultry - virology
• ISSN: 0022-5193; 1095-8541
• DOI: 10.1016/j.jtbi.2014.12.002

In 2013 in China a new type of avian influenza virus, H7N9, began to infect humans and had aroused severe fatality in the infected humans. We know that the spread is from poultry to humans, and the H7N9 avian influenza is low pathogenic in the poultry world but highly pathogenic in the human world, but the transmission mechanism is unclear. Since it has no signs of human-to-human transmission and outbreaks are isolated in some cities in China, in order to investigate the transmission mechanism of human infection with H7N9 avian influenza, an eco-epidemiological model in an outbreak region is proposed and analyzed dynamically. Researches and reports show that gene mutation makes the new virus be capable of infecting humans, therefore the mutation factor is taken into account in the model. The global dynamic analysis is conducted, different thresholds are identified, persistence and global qualitative behaviors are obtained. The impact of H7N9 avian influenza on the people population is concerned. Finally, the numerical simulations are carried out to support the theoretical analysis and to investigate the disease control measures. It seems that we may take people׳s hygiene and prevention awareness factor as a significant policy to achieve the aim of both the disease control and the economic returns.