The Anti-Osteoporosis and Antioxidant Activities of Chemical Constituents from Chrysanthemum indicum Flowers

Two new compounds, chrysinoneside A (1) and (−)‐trans‐chrysanthenol‐6‐O‐β‐D‐glucopyranoside (2), along with 17 known compounds (3–19) were isolated from Chrysanthemum indicum flowers. The total phenolic and flavonoid contents of various fractions were determined. The EtOAC fraction had the highest t...

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Bibliographic Details
Published in:Phytotherapy research 2015-04, Vol.29 (4), p.540-548
Main Authors: Luyen, Bui Thi Thuy, Tai, Bui Huu, Thao, Nguyen Phuong, Lee, Young Mi, Lee, Sang Hyun, Jang, Hae Dong, Kim, Young Ho
Format: Article
Language:English
Subjects:
(−)-trans-Chrysanthenol-6-O-β-D-glucopyranoside
Acid Phosphatase - metabolism
Animals
anti-osteoporosis activity
antioxidant activity
Antioxidants - pharmacology
Cell Differentiation - drug effects
Cell Line
Chrysanthemum
Chrysanthemum - chemistry
Chrysanthemum indicum
chrysinoneside A
Flavonoids - pharmacology
Flowers - chemistry
Isoenzymes - metabolism
Mice
Molecular Structure
Osteoclasts - drug effects
Osteoclasts - metabolism
Osteoporosis
Oxidation-Reduction
Phenols - pharmacology
Plant Extracts - pharmacology
RANK Ligand - metabolism
Tartrate-Resistant Acid Phosphatase
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Summary:Two new compounds, chrysinoneside A (1) and (−)‐trans‐chrysanthenol‐6‐O‐β‐D‐glucopyranoside (2), along with 17 known compounds (3–19) were isolated from Chrysanthemum indicum flowers. The total phenolic and flavonoid contents of various fractions were determined. The EtOAC fraction had the highest total phenolic content (525.84 ± 23.51 mg GAE/g DR) and the total flavonoid content (63.49 ± 3.32 mg QE/g DR). The EtOAc and water fractions showed the greatest peroxyl radical‐scavenging capacity and the ability to reduce Cu(I) ions, with ORAC and CUPRAC values ranging from 24.00 ± 0.44 to 28.06 ± 1.35 and 16.90 ± 0.51 to 49.77 ± 0.97 μM, respectively. Compounds 5–11, 18, and 19 displayed strong effects in both peroxyl radical‐scavenging and reducing capacity assays at a concentration of 10 μM. The anti‐osteoporosis activity of these compounds was also evaluated. Compounds 10, 13, and 19 exhibited the most potent tartrate‐resistant acid phosphatase activity in receptor activator of nuclear factor‐κB ligand‐induced osteoclastic RAW 264.7 cells with values of 105.95 ± 1.18, 110.32 ± 3.95, and 112.58 ± 6.42%, respectively. Copyright © 2015 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.5281