Protective effects of yacon (Smallanthus sonchifolius) intake on experimental colon carcinogenesis

► We investigated the potential beneficial of yacon intake on rat colon carcinogenesis. ► Yacon treatment inhibits the development of aberrant crypt foci and colon tumor. ► Cell proliferation was also reduced in the groups orally treated with dietary yacon. ► Yacon root is a potential chemopreventiv...

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Bibliographic Details
Published in:Food and chemical toxicology 2012-08, Vol.50 (8), p.2902-2910
Main Authors: de Moura, Nelci A., Caetano, Brunno F.R., Sivieri, Kátia, Urbano, Luis H., Cabello, Claudio, Rodrigues, Maria A.M., Barbisan, Luis F.
Format: Article
Language:English
Subjects:
1,2-dimethylhydrazine
1,2-Dimethylhydrazine - toxicity
adenocarcinoma
Animals
Asteraceae
Biological and medical sciences
Cancer chemoprevention
carcinogenesis
Carcinogenesis, carcinogens and anticarcinogens
Carcinogens - toxicity
Cell Proliferation
Chemical agents
colon
Colon carcinogenesis
Colonic Neoplasms - chemically induced
Colonic Neoplasms - pathology
Colonic Neoplasms - prevention & control
colorectal neoplasms
diet
fructans
Gastroenterology. Liver. Pancreas. Abdomen
Immunohistochemistry
Lactobacillus casei
Male
Medical sciences
protective effect
Rat
Rats
Rats, Wistar
short chain fatty acids
Smallanthus
Smallanthus sonchifolius
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
toxicology
Tumors
Yacon root
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Summary:► We investigated the potential beneficial of yacon intake on rat colon carcinogenesis. ► Yacon treatment inhibits the development of aberrant crypt foci and colon tumor. ► Cell proliferation was also reduced in the groups orally treated with dietary yacon. ► Yacon root is a potential chemopreventive agent against colon carcinogenesis. Yacon (Smallanthus sonchifolius), a tuberous root native to the Andean region of South America, contains high concentration of fructans with potential for colon cancer prevention. This study investigated the potential beneficial of yacon intake on colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH) in male Wistar rats. After 4weeks of DMH-initiation, groups were fed basal diet (G1 and G6) or basal diet containing dried extract of yacon root at 0.5% (G2), 1.0% (G3 and G5) or a synbiotic formulation (G4) (1.0% yacon plus Lactobacillus casei at 2.5×1010CFU per g diet) for 13weeks. At week 20, a significant reduction in number and multiplicity of aberrant crypt foci (ACF) and in number of invasive adenocarcinomas was observed in the groups orally treated with 1.0% yacon (G3) or the synbiotic formulation (G4) (0.05
ISSN:0278-6915
1873-6351
DOI:10.1016/j.fct.2012.05.006