Lower maximum standardized uptake value of fluorine-18 fluorodeoxyglucose positron emission tomography coupled with computed tomography imaging in pancreatic ductal adenocarcinoma patients with diabetes

• Published in: The American journal of surgery 2015-04, Vol.209 (4), p.709-716
• Main Authors: Chung, Kwang Hyun, M.D, Park, Joo Kyung, M.D, Lee, Sang Hyub, M.D., Ph.D, Hwang, Dae Wook, M.D., Ph.D, Cho, Jai Young, M.D., Ph.D, Yoon, Yoo-Seok, M.D., Ph.D, Han, Ho-Seong, M.D., Ph.D, Hwang, Jin-Hyeok, M.D., Ph.D
• Format: Article
• Language: English
• Subjects: Aged; Antigens; Body mass index; Cancer therapies; Carbohydrates; Carcinoma; Carcinoma, Pancreatic Ductal - complications; Carcinoma, Pancreatic Ductal - diagnosis; Carcinoma, Pancreatic Ductal - metabolism; Confidence intervals; Diabetes; Diabetes Complications - diagnosis; Diabetes Complications - metabolism; Diabetes mellitus; Female; Fluorine; Fluorodeoxyglucose F18 - pharmacokinetics; Glucose; Humans; Hyperglycemia; Hypertension; Laboratories; Male; Medical imaging; Middle Aged; Mortality; Multimodal Imaging; Multivariate analysis; Pancreatic cancer; Pancreatic ductal; Pancreatic Neoplasms - complications; Pancreatic Neoplasms - diagnosis; Pancreatic Neoplasms - metabolism; Patients; Plasma; Positron emission tomography and computed tomography; Positron-Emission Tomography; Radiation therapy; Retrospective Studies; Standardized uptake value; Surgery; Tomography; Tomography, X-Ray Computed; Tumors
• ISSN: 0002-9610; 1879-1883
• DOI: 10.1016/j.amjsurg.2014.06.038

Abstract Background The effects of diabetes mellitus (DM) on sensitivity of fluorine-18 fluorodeoxyglucose positron emission tomography coupled with computed tomography (18 F-FDG PET/CT) for diagnosing pancreatic ductal adenocarcinomas (PDACs) is not well known. This study was aimed to evaluate the effects of DM on the validity of18 F-FDG PET/CT in PDAC. Methods A total of 173 patients with PDACs who underwent18 F-FDG PET/CT were enrolled (75 in the DM group and 98 in the non-DM group). The maximum standardized uptake values (SUVsmax ) were compared. Results The mean SUVmax was significantly lower in the DM group than in the non-DM group (4.403 vs 5.998, P = .001). The sensitivity of SUVmax (cut-off value 4.0) was significantly lower in the DM group than in the non-DM group (49.3% vs 75.5%, P < .001) and also lower in normoglycemic DM patients (n = 24) than in non-DM patients (54.2% vs 75.5%, P = .038). Conclusion DM contributes to a lower SUVmax of18 F-FDG PET/CT in patients with PDACs.