Bamboo salt reduces allergic responses by modulating the caspase-1 activation in an OVA-induced allergic rhinitis mouse model

• Published in: Food and chemical toxicology 2012-10, Vol.50 (10), p.3480-3488
• Main Authors: Kim, Kyu-Yeob, Nam, Sun-Young, Shin, Tae-Yong, Park, Kun-Young, Jeong, Hyun-Ja, Kim, Hyung-Min
• Format: Article
• Language: English
• Subjects: Allergic rhinitis; animal models; Animals; anti-inflammatory activity; Bamboo salt; bamboos; Bambusa - chemistry; Biological and medical sciences; blood serum; breathing; Caspase 1 - metabolism; Caspase-1; Cell Line; Cytokines - genetics; Cytokines - metabolism; eosinophils; Food Handling; histamine; Histamine - metabolism; Humans; IL-1β; immunoglobulin E; Immunoglobulin E - blood; interferon-gamma; interleukin-1beta; interleukin-4; intranasal administration; magnesium; Mast Cells; Medical sciences; Mice; Nasal Mucosa; Non tumoral diseases; oral administration; Otorhinolaryngology. Stomatology; ovalbumin; Ovalbumin - immunology; potassium; rhinitis; Rhinitis, Allergic; Rhinitis, Allergic, Perennial - chemically induced; Rhinitis, Allergic, Perennial - drug therapy; sodium chloride; Sodium Chloride, Dietary - analysis; solar drying; spleen; Toxicology; TSLP; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology; zinc
• ISSN: 0278-6915; 1873-6351
• DOI: 10.1016/j.fct.2012.07.017

[Display omitted] ► The symptoms of allergic rhinitis related with release of histamine, inflammatory cytokines and other active substances. ► Bamboo salt inhibited histamine and IgE levels. ► Bamboo salt also inhibits L-1β production and caspase-1 activity. Bamboo salt (BS) is a specially processed salt according to the traditional recipe using sun-dried salt (SDS) and bamboo in Korea. The present study investigated the effects and mechanism of BS, SDS, NaCl, or mineral mixture (containing zinc, magnesium, and potassium) on ovalbumin (OVA)-induced allergic rhinitis (AR) animal model. The increased number of rubs was inhibited by the oral administration of BS, SDS, NaCl, mineral mixture, or nose inhalation of BS. The increased levels of IgE, histamine, and interleukin (IL)-1β in serum were reduced by BS. The level of interferon-γ was increased, whereas the level of IL-4 was reduced on the spleen tissue of BS-treated mice. In the BS-treated mice, the number of eosinophils and mast cells infiltration increased by OVA-sensitization were also decreased. Protein levels of inflammatory cytokines were reduced by BS or NaCl administration in the nasal mucosa of the AR mice. In addition, BS inhibited caspase-1 activity in the nasal mucosa tissue. In activated human mast cells, BS significantly inhibited the production of IL-1β and thymic stromal lymphopoietin and activation of caspase-1. Our data indicate that BS has anti-allergic and anti-inflammatory effects by regulating of caspase-1 activation in AR mice and in vitro models.