Complete genomic characterization of two tick-borne encephalitis viruses isolated from China

Tick-borne encephalitis (TBEV) is prevalent over a wide area of the Eurasian continent. TBE viruses cause severe encephalitis in humans, with serious sequelae, and have a significant impact on public health in these endemic regions. To gain insight into genetic evolution of tick-borne encephalitis v...

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Bibliographic Details
Published in:Virus research 2012-08, Vol.167 (2), p.310-313
Main Authors: Zhang, Yu, Si, Bing-Yin, Liu, Bo-Hua, Chang, Guo-Hui, Yang, Yin-Hui, Huo, Qiu-Bo, Zheng, Yuan-Chun, Zhu, Qing-Yu
Format: Article
Language:English
Subjects:
China
Cluster Analysis
Complete genomic characterization
complications (disease)
Encephalitis Viruses, Tick-Borne - genetics
Encephalitis Viruses, Tick-Borne - isolation & purification
genes
Genome, Viral
Humans
Molecular Sequence Data
nucleotides
open reading frames
Phylogeny
public health
RNA, Viral - genetics
Sequence Analysis, DNA
Sequence Deletion
Sequence Homology, Nucleic Acid
tick-borne encephalitis
Tick-borne encephalitis virus
Tick-borne encephalitis viruses
vaccines
viruses
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Summary:Tick-borne encephalitis (TBEV) is prevalent over a wide area of the Eurasian continent. TBE viruses cause severe encephalitis in humans, with serious sequelae, and have a significant impact on public health in these endemic regions. To gain insight into genetic evolution of tick-borne encephalitis virus (TBEV) in China, the complete genomic sequences of two TBEV strains Senzhang and MDJ01, which were isolated in 1953 and 2001 respectively, were characterized. The complete genome sequences of two strains were all consist 10,784 nucleotides and there are 364 nucleotides deletion in the 3′ nontranslated region. Compared with other TBEV strains, homology range from 85.2% (Zausaev) to 99.6% (MDJ02 and MDJ03) on the level of nucleotide. Phylogenetic trees based on the complete genome, open reading frame and E gene nucleotide sequences all showed that the strains Senzhang and MDJ01 belong to Far-Eastern subtype and cluster with other Chinese TBEV strains. All these implied that TBEVs prevalent in China were highly conservative, other measurement should be taken to improve protective efficacy of present vaccine.
ISSN:0168-1702
1872-7492
DOI:10.1016/j.virusres.2012.05.015