A new isoquinoline alkaloid with anti-microbial properties from Berberis jaeschkeana Schneid. var. jaeschkeana

One new isoquinoline alkaloid named berberidione (1) along with four new source alkaloids berberine (2), palmatine (3), jatrorrhizine (4) and chondrofoline (5) and three new source non-alkaloids syringic acid (6), β-sitosterol (7) and stigmasterol (8) was isolated and characterised from different fr...

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Bibliographic Details
Published in:Natural product research 2015-04, Vol.29 (8), p.692-697
Main Authors: Alamzeb, Muhammad, Khan, M. Rafiullah, Ali, Saqib, Khan, Ashfaq Ahmad
Format: Article
Language:English
Subjects:
Alkaloids - chemistry
Alkaloids - isolation & purification
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
anti-microbial
berberidione
Berberis
Berberis - chemistry
Berberis jaeschkeana
Cell Line
Humans
Isoquinolines - chemistry
Isoquinolines - isolation & purification
Molecular Structure
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Summary:One new isoquinoline alkaloid named berberidione (1) along with four new source alkaloids berberine (2), palmatine (3), jatrorrhizine (4) and chondrofoline (5) and three new source non-alkaloids syringic acid (6), β-sitosterol (7) and stigmasterol (8) was isolated and characterised from different fractions of Berberis jaeschkeana Schneid var. jaeschkeana. All the structures were determined from 1D and 2D spectroscopic data. Crude extract, sub-fractions and isolated compounds showed excellent anti-microbial properties. The toxicity level for the alkaloids was found to be very low on THP-1 cells.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2014.981187