Transitory effect on endolymphatic hydrops of the intratympanic steroids for Ménière's disease

Objectives/Hypothesis This study aimed to evaluate the changes in electrocochleography (EcohG) measurements after intratympanic (IT) dexamethasone therapy and to correlate them with the long‐term effects on the control of vertigo. Study Design Prospective outcomes research. Methods This study includ...

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Bibliographic Details
Published in:The Laryngoscope 2015-05, Vol.125 (5), p.1183-1188
Main Authors: Martin-Sanz, Eduardo, Esteban-Sanchez, Jonathan, Rodrigañez-Riesco, Laura, Sanz-Fernández, Ricardo
Format: Article
Language:English
Subjects:
Audiometry, Evoked Response
Dexamethasone - administration & dosage
Ear, Middle
electrocochleography
endolymphatic hydrops
Endolymphatic Hydrops - drug therapy
Female
Follow-Up Studies
Glucocorticoids - administration & dosage
Humans
intratympanic steroids
Kaplan-Meier
Male
Meniere Disease - drug therapy
Middle Aged
Ménière's disease
Prospective Studies
Time Factors
Treatment Outcome
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Summary:Objectives/Hypothesis This study aimed to evaluate the changes in electrocochleography (EcohG) measurements after intratympanic (IT) dexamethasone therapy and to correlate them with the long‐term effects on the control of vertigo. Study Design Prospective outcomes research. Methods This study included 62 patients with unilateral Ménière's Disease (MD) refractory to medical therapy for at least 1 year. Each patient was treated with a fixed protocol of three consecutive weekly injections of a commercial 4 mg/mL dexamethasone preparation. The 1995 American Academy of Otolaryngology–Head and Neck Surgery (AAO–HNS) criteria for reporting treatment outcomes for MD were used. Electrocochleography (EcohG) measurements were performed 1 month before and 1 and 12 months after IT steroid therapy. Caloric test and vestibular evoked myogenic potential (VEMPs) were performed before the IT treatment. The summating potential/action potential (SP/AP) ratio was measured before and after the IT treatment. A Kaplan‐Meier analysis was used to evaluate the control of vertigo over a 2‐year period. Results Complete vertigo control (class A) was achieved in 26 patients (41.9%) at the 12‐month follow‐up and in 12 patients (19.3%) at the 24‐month follow‐up. A significant reduction (P 
ISSN:0023-852X
1531-4995
DOI:10.1002/lary.25057