Blood Oxygen Saturation After Ischemia is Altered With Abnormal Microvascular Reperfusion

Objective We have previously described a distinct abnormality in the cutaneous microcirculation that is characterized by an abnormal reperfusion response following an ischemic stimulus. We investigated the physiological significance of this abnormality; by measuring microvascular perfusion and blood...

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Bibliographic Details
Published in:Microcirculation (New York, N.Y. 1994) N.Y. 1994), 2015-05, Vol.22 (4), p.294-305
Main Authors: Adingupu, Damilola D., Thorn, Clare E., Casanova, Francesco, Elyas, Salim, Gooding, Kim, Gilchrist, Mark, Aizawa, Kunihiko, Gates, Phillip E., Shore, Angela C., Strain, David W.
Format: Article
Language:English
Subjects:
Adult
Aged
Female
Humans
ischemia
Ischemia - blood
Ischemia - physiopathology
Male
Microcirculation
microvascular blood flow regulation
Middle Aged
oxygen
Oxygen - blood
Skin - blood supply
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Summary:Objective We have previously described a distinct abnormality in the cutaneous microcirculation that is characterized by an abnormal reperfusion response following an ischemic stimulus. We investigated the physiological significance of this abnormality; by measuring microvascular perfusion and blood oxygen saturation in groups stratified by three distinct reperfusion responses. Methods Cutaneous microvascular reperfusion after four minutes of arterial occlusion above the ankle was measured on the foot using laser Doppler fluximetry and optical reflectance spectroscopy in almost 400 adults. Individuals were stratified into three groups according to the microvascular reperfusion response: normal and two abnormal patterns (DEP and NDEP). Results Our main findings were that abnormal microvascular reperfusion responses (DEP and NDEP) had a higher baseline oxygen saturation (p = 0.005), a lower plateau in oxygen saturation (p 
ISSN:1073-9688
1549-8719
DOI:10.1111/micc.12198