Androprostamines A and B, the new anti-prostate cancer agents produced by Streptomyces sp. MK932-CF8

Androgen receptor (AR) is a validated target in all clinical states of prostate cancer. Androprostamines A and B, the new inhibitors of androgen receptor, were isolated from Streptomyces sp. MK932-CF8. Their structures were determined by the spectroscopic analysis, degradation studies and synthesis....

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Bibliographic Details
Published in:Journal of antibiotics 2015-04, Vol.68 (4), p.279-285
Main Authors: Yamazaki, Yohko, Someno, Tetsuya, Igarashi, Masayuki, Kinoshita, Naoko, Hatano, Masaki, Kawada, Manabu, Momose, Isao, Nomoto, Akio
Format: Article
Language:English
Subjects:
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Androgen Receptor Antagonists - isolation & purification
Androgen Receptor Antagonists - pharmacology
Androgens
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
Bacteriology
Biomedical and Life Sciences
Bioorganic Chemistry
Cell Line, Tumor
Cinnamates - isolation & purification
Cinnamates - pharmacology
Cytotoxicity
Gene Expression Regulation, Neoplastic
Humans
Life Sciences
Male
Medicinal Chemistry
Microbiology
Oligopeptides - isolation & purification
Oligopeptides - pharmacology
Organic Chemistry
original-article
Prostate cancer
Prostatic Neoplasms - drug therapy
Prostatic Neoplasms - genetics
Prostatic Neoplasms - pathology
Receptors, Androgen - drug effects
Receptors, Androgen - genetics
Streptomyces - metabolism
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Summary:Androgen receptor (AR) is a validated target in all clinical states of prostate cancer. Androprostamines A and B, the new inhibitors of androgen receptor, were isolated from Streptomyces sp. MK932-CF8. Their structures were determined by the spectroscopic analysis, degradation studies and synthesis. Androprostamines showed potent inhibitory effect against androgen-dependent growth of human prostate cancer cells without cytotoxicity and repressed the androgen-induced expression of AR-regulated genes.
ISSN:0021-8820
1881-1469
DOI:10.1038/ja.2014.135