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Androprostamines A and B, the new anti-prostate cancer agents produced by Streptomyces sp. MK932-CF8
Androgen receptor (AR) is a validated target in all clinical states of prostate cancer. Androprostamines A and B, the new inhibitors of androgen receptor, were isolated from Streptomyces sp. MK932-CF8. Their structures were determined by the spectroscopic analysis, degradation studies and synthesis....
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| Published in: | Journal of antibiotics 2015-04, Vol.68 (4), p.279-285 |
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| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c509t-cba11c7bb6a26c02ee66a9d76fd04dd540afa2a97b8eb046211df665890757963 |
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| cites | cdi_FETCH-LOGICAL-c509t-cba11c7bb6a26c02ee66a9d76fd04dd540afa2a97b8eb046211df665890757963 |
| container_end_page | 285 |
| container_issue | 4 |
| container_start_page | 279 |
| container_title | Journal of antibiotics |
| container_volume | 68 |
| creator | Yamazaki, Yohko Someno, Tetsuya Igarashi, Masayuki Kinoshita, Naoko Hatano, Masaki Kawada, Manabu Momose, Isao Nomoto, Akio |
| description | Androgen receptor (AR) is a validated target in all clinical states of prostate cancer. Androprostamines A and B, the new inhibitors of androgen receptor, were isolated from
Streptomyces
sp. MK932-CF8. Their structures were determined by the spectroscopic analysis, degradation studies and synthesis. Androprostamines showed potent inhibitory effect against androgen-dependent growth of human prostate cancer cells without cytotoxicity and repressed the androgen-induced expression of AR-regulated genes. |
| doi_str_mv | 10.1038/ja.2014.135 |
| format | article |
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Streptomyces
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| ispartof | Journal of antibiotics, 2015-04, Vol.68 (4), p.279-285 |
| issn | 0021-8820 1881-1469 |
| language | eng |
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| source | Springer Nature |
| subjects | 692/308/153 82/47 96 Androgen Receptor Antagonists - isolation & purification Androgen Receptor Antagonists - pharmacology Androgens Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Bacteriology Biomedical and Life Sciences Bioorganic Chemistry Cell Line, Tumor Cinnamates - isolation & purification Cinnamates - pharmacology Cytotoxicity Gene Expression Regulation, Neoplastic Humans Life Sciences Male Medicinal Chemistry Microbiology Oligopeptides - isolation & purification Oligopeptides - pharmacology Organic Chemistry original-article Prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Receptors, Androgen - drug effects Receptors, Androgen - genetics Streptomyces - metabolism |
| title | Androprostamines A and B, the new anti-prostate cancer agents produced by Streptomyces sp. MK932-CF8 |
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