Sustained delivery of exogenous melatonin influences biomarkers of oxidative stress and total antioxidant capacity in summer-stressed anestrous water buffalo (Bubalus bubalis)

High ambient temperature during summer in tropical and subtropical countries predisposes water buffaloes (Bubalus bubalis) to develop oxidative stress having antigonadotropic and antisteroidogenic actions. Melatonin is a regulator of seasonal reproduction in photoperiodic species and highly effectiv...

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Bibliographic Details
Published in:Theriogenology 2015-06, Vol.83 (9), p.1402-1407
Main Authors: Kumar, Ashok, Mehrotra, S., Singh, G., Narayanan, K., Das, G.K., Soni, Y.K., Singh, Mahak, Mahla, A.S., Srivastava, N., Verma, M.R.
Format: Article
Language:English
Subjects:
Anestrus - metabolism
Animals
Antioxidants - metabolism
Buffaloes - metabolism
Female
Free radical
Heat-Shock Response
Malondialdehyde
Malondialdehyde - blood
Melatonin - pharmacology
Nitric oxide
Nitric Oxide - blood
Oxidative Stress
Reactive oxygen species
Seasons
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Summary:High ambient temperature during summer in tropical and subtropical countries predisposes water buffaloes (Bubalus bubalis) to develop oxidative stress having antigonadotropic and antisteroidogenic actions. Melatonin is a regulator of seasonal reproduction in photoperiodic species and highly effective antioxidant and free radical scavenger. Therefore, a study was designed to evaluate the effect of sustained-release melatonin on biomarkers of oxidative stress i.e., the serum malondialdehyde (MDA) and nitric oxide (NO), and the total antioxidant capacity (TAC). For the study, postpartum buffaloes diagnosed as summer anestrus (absence of overt signs of estrus, concurrent rectal examination, and RIA for serum progesterone) were grouped as treated (single subcutaneous injection of melatonin at 18 mg/50 kg body weight dissolved in sterilized corn oil as vehicle, n = 20) and untreated (subcutaneous sterilized corn oil, n = 8). Blood sampling for estimation of serum TAC and MDA (mmol/L) and NO (μmol/L) was carried out at 4 days of interval from 8 days before treatment till 28 days after treatment or for the ensuing entire cycle length. Results showed serum TAC concentration was higher in the treatment group with a significant (P 
ISSN:0093-691X
1879-3231
DOI:10.1016/j.theriogenology.2014.12.023