Agents that inhibit bacterial biofilm formation

In the biofilm form, bacteria are more resistant to various antimicrobial treatments. Bacteria in a biofilm can also survive harsh conditions and withstand the host's immune system. Therefore, there is a need for new treatment options to treat biofilm-associated infections. Currently, research...

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Bibliographic Details
Published in:Future medicinal chemistry 2015-01, Vol.7 (5), p.647-671
Main Authors: Rabin, Nira, Zheng, Yue, Opoku-Temeng, Clement, Du, Yixuan, Bonsu, Eric, Sintim, Herman O
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Bacteria - drug effects
Bacterial Infections - drug therapy
Biofilms - drug effects
Drug Discovery - methods
Humans
Microbial Sensitivity Tests
Small Molecule Libraries - chemistry
Small Molecule Libraries - pharmacology
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Summary:In the biofilm form, bacteria are more resistant to various antimicrobial treatments. Bacteria in a biofilm can also survive harsh conditions and withstand the host's immune system. Therefore, there is a need for new treatment options to treat biofilm-associated infections. Currently, research is focused on the development of antibiofilm agents that are nontoxic, as it is believed that such molecules will not lead to future drug resistance. In this review, we discuss recent discoveries of antibiofilm agents and different approaches to inhibit/disperse biofilms. These new antibiofilm agents, which contain moieties such as imidazole, phenols, indole, triazole, sulfide, furanone, bromopyrrole, peptides, etc. have the potential to disperse bacterial biofilms in vivo and could positively impact human medicine in the future.
ISSN:1756-8919
1756-8927
DOI:10.4155/fmc.15.7