Can we compare serum sclerostin results obtained with different assays in hemodialysis patients?

Purpose Sclerostin, secreted by osteocytes, plays a key role in antagonizing bone formation. Recent studies, which seldom include chronic kidney disease (CKD) patients, have reported on the association of sclerostin and mortality, with contradictory results. The assay-linked variability may contribu...

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Bibliographic Details
Published in:International urology and nephrology 2015-05, Vol.47 (5), p.847-850
Main Authors: Moysés, Rosa M. A., Jamal, Sophie A., Graciolli, Fabiana G., dos Reis, Luciene M., Elias, Rosilene M.
Format: Article
Language:English
Subjects:
Adult
Alkaline Phosphatase - blood
beta 2-Microglobulin - blood
Bone Diseases, Metabolic - blood
Bone Diseases, Metabolic - etiology
Bone Morphogenetic Proteins - blood
Calcitonin - blood
Enzyme-Linked Immunosorbent Assay - methods
Female
Fibroblast Growth Factors - blood
Genetic Markers
Humans
Interleukin-6 - blood
Male
Medicine
Medicine & Public Health
Middle Aged
Nephrology
Nephrology - Original Paper
Parathyroid Hormone - blood
Renal Dialysis
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - complications
Renal Insufficiency, Chronic - therapy
Urology
Young Adult
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Summary:Purpose Sclerostin, secreted by osteocytes, plays a key role in antagonizing bone formation. Recent studies, which seldom include chronic kidney disease (CKD) patients, have reported on the association of sclerostin and mortality, with contradictory results. The assay-linked variability may contribute to these discrepant results. Methods We have compared sclerostin results obtained with two assays (TECO and Biomedica) in a cohort of 91 CKD patients undergoing hemodialysis. Results We found a strong correlation ( r  = 0.870, p  
ISSN:0301-1623
1573-2584
DOI:10.1007/s11255-015-0971-7