Effects of propofol and sevoflurane on isolated human umbilical arteries pre‐contracted with dopamine, adrenaline and noradrenaline

• Published in: The journal of obstetrics and gynaecology research 2015-05, Vol.41 (5), p.697-703
• Main Authors: Gunduz, Ergun, Arun, Oguzhan, Bagci, Sengal Taylan, Oc, Bahar, Salman, Alper, Yilmaz, Setenay Arzu, Celik, Cetin, Duman, Ates
• Format: Article
• Language: English
• Subjects: adrenaline; Adult; Anesthetics, Intravenous - pharmacology; dopamine; Dopamine - pharmacology; Epinephrine - pharmacology; Female; Humans; Methyl Ethers - pharmacology; noradrenaline; Norepinephrine - pharmacology; Pregnancy; propofol; Propofol - pharmacology; sevoflurane; Umbilical Arteries - drug effects; umbilical artery; Vasoconstriction - drug effects; Young Adult
• ISSN: 1341-8076; 1447-0756
• DOI: 10.1111/jog.12624

Aim To assess the effects of propofol and sevoflurane on the contraction elicited by dopamine, adrenaline and noradrenaline on isolated human umbilical arteries. Methods Umbilical arteries were cut into endothelium‐denuded spiral strips and suspended in organ baths containing Krebs–Henseleit solution bubbled with O2+CO2 mixture. Control contraction to phenylephrine (10−5 M) was recorded. Response curves were obtained to 10−5 M dopamine, 10−5 M adrenaline or 10−5 M noradrenaline. Afterwards, either cumulative propofol (10−6 M, 10−5 M and 10−4 M) or cumulative sevoflurane (1.2%, 2.4% and 3.6%) was added to the organ bath, and the responses were recorded. Responses are expressed percentage of phenylephrine‐induced contraction (mean ± standard deviation) (P