Immune-related pathways including HLA-DRB1∗ 13:02 are associated with panic disorder

Highlights • We performed pathway analyses using GWAS data for panic disorder (PD). • Pathways related to immunity were significantly associated with PD. • We genotyped HLA-B and HLA-DRB1 region as susceptibility loci for PD. • PD patients were significantly more likely to carry HLA-DRB1∗13:02 than...

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Published in:Brain, behavior, and immunity behavior, and immunity, 2015-05, Vol.46, p.96-103
Main Authors: Shimada-Sugimoto, Mihoko, Otowa, Takeshi, Miyagawa, Taku, Khor, Seik-Soon, Kashiwase, Koichi, Sugaya, Nagisa, Kawamura, Yoshiya, Umekage, Tadashi, Kojima, Hiroto, Saji, Hiroh, Miyashita, Akinori, Kuwano, Ryozo, Kaiya, Hisanobu, Kasai, Kiyoto, Tanii, Hisashi, Okazaki, Yuji, Tokunaga, Katsushi, Sasaki, Tsukasa
Format: Article
Language:English
Subjects:
Adult
Allergy and Immunology
Female
Gene Frequency
Genetic Predisposition to Disease
Genome-Wide Association Study
Haplotypes
HLA-B
HLA-DRB1
HLA-DRB1 Chains - genetics
Human Leukocyte Antigen
Humans
Immunity
Male
Middle Aged
Panic disorder
Panic Disorder - genetics
Pathway analysis
Polymorphism, Single Nucleotide
Psychiatry
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Summary:Highlights • We performed pathway analyses using GWAS data for panic disorder (PD). • Pathways related to immunity were significantly associated with PD. • We genotyped HLA-B and HLA-DRB1 region as susceptibility loci for PD. • PD patients were significantly more likely to carry HLA-DRB1∗13:02 than controls.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2015.01.002