Signalling by Receptor Tyrosine Kinases

The field of signal transduction by RTKs has expanded dramatically within the past five years. Therefore, it is not possible to cover this area exhaustively. The focus of this review is on receptors. Excellent reviews of the signalling molecules, PI3-kinase, PLC- gamma , Raf, and ERK kinases have be...

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Bibliographic Details
Published in:Annual review of biochemistry 1993-01, Vol.62 (1), p.453-481
Main Authors: Fantl, W J, Johnson, D E, Williams, L T
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell physiology
Fundamental and applied biological sciences. Psychology
Growth Substances - metabolism
Molecular and cellular biology
Mutagenesis
Phosphotyrosine
Protein-Tyrosine Kinases - physiology
Receptors, Cell Surface - genetics
Receptors, Cell Surface - physiology
Signal transduction
Signal Transduction - genetics
Signal Transduction - physiology
Tyrosine - analogs & derivatives
Tyrosine - metabolism
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Summary:The field of signal transduction by RTKs has expanded dramatically within the past five years. Therefore, it is not possible to cover this area exhaustively. The focus of this review is on receptors. Excellent reviews of the signalling molecules, PI3-kinase, PLC- gamma , Raf, and ERK kinases have been recently published. Also, we do not discuss the modification of cytoskeletal proteins in response to growth factors. We include information on p21ras because this field has progressed rapidly during the past year. The review is organized into a section on general approaches to studies of receptor-mediated signal transduction, with an emphasis on genetic and biochemical studies, followed by a brief discussion of each subfamily of receptors emphasizing that group's idiosyncrasies.
ISSN:0066-4154
1545-4509
DOI:10.1146/annurev.bi.62.070193.002321