Comparison of acetate inhibition on growth of host and recombinant E. coli K12 strains

We investigated the extent of acetate inhibition on growth rate of different host and recombinant E. coli K12 strains, cultivated in defined and complex media. A mathematical model was proposed to describe this inhibition. Our results show that acetate inhibition is more significant for recombinant...

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Bibliographic Details
Published in:Biotechnology letters 1992-01, Vol.14 (12), p.1115-1118
Main Authors: BOON TONG KOH, NAKASHIMADA, U, PFEIFFER, M, YAP, M. G. S
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biology of microorganisms of confirmed or potential industrial interest
Biotechnology
Escherichia coli
Fundamental and applied biological sciences. Psychology
Genetics
Mission oriented research
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Summary:We investigated the extent of acetate inhibition on growth rate of different host and recombinant E. coli K12 strains, cultivated in defined and complex media. A mathematical model was proposed to describe this inhibition. Our results show that acetate inhibition is more significant for recombinant cells than for host cells, and for cells cultured in defined medium than in complex medium.
ISSN:0141-5492
1573-6776
DOI:10.1007/BF01027012