Combination of arterial lactate levels and venous-arterial CO2 to arterial-venous O 2 content difference ratio as markers of resuscitation in patients with septic shock

To evaluate the prognostic value of the Cv-aCO2/Da-vO2 ratio combined with lactate levels during the early phases of resuscitation in septic shock. Prospective observational study in a 60-bed mixed ICU. One hundred and thirty-five patients with septic shock were included. The resuscitation protocol...

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Bibliographic Details
Published in:Intensive care medicine 2015-05, Vol.41 (5), p.796-805
Main Authors: Ospina-Tascón, Gustavo A, Umaña, Mauricio, Bermúdez, William, Bautista-Rincón, Diego F, Hernandez, Glenn, Bruhn, Alejandro, Granados, Marcela, Salazar, Blanca, Arango-Dávila, César, De Backer, Daniel
Format: Article
Language:English
Subjects:
Aged
Biomarkers - blood
Blood Gas Analysis
Carbon Dioxide - blood
Female
Humans
Lactic Acid - blood
Male
Middle Aged
Oxygen - blood
Prognosis
Prospective Studies
Resuscitation
Risk Assessment
Shock, Septic - blood
Shock, Septic - therapy
Survival Analysis
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Summary:To evaluate the prognostic value of the Cv-aCO2/Da-vO2 ratio combined with lactate levels during the early phases of resuscitation in septic shock. Prospective observational study in a 60-bed mixed ICU. One hundred and thirty-five patients with septic shock were included. The resuscitation protocol targeted mean arterial pressure, pulse pressure variations or central venous pressure, mixed venous oxygen saturation, and lactate levels. Patients were classified into four groups according to lactate levels and Cv-aCO2/Da-vO2 ratio at 6 h of resuscitation (T6): group 1, lactate ≥2.0 mmol/L and Cv-aCO2/Da-vO2 >1.0; group 2, lactate ≥2.0 mmol/L and Cv-aCO2/Da-vO2 ≤1.0; group 3, lactate 1.0; and group 4, lactate
ISSN:1432-1238
DOI:10.1007/s00134-015-3720-6