The potential of cytotherapeutics in hematologic reconstitution and in the treatment and prophylaxis of graft-versus-host disease. Chapter I: current practice and remaining unmet medical needs

Hematopoietic stem cell transplantation is a life-saving treatment for inherited anemias, immunodeficiencies or hematologic malignancies. When using partially HLA-matched allografts, a major complication is graft-versus-host disease (GvHD). The ideal attributes of a transformational new GvHD treatme...

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Bibliographic Details
Published in:Regenerative medicine 2015-05, Vol.10 (3), p.331-343
Main Author: Vertès, Alain A
Format: Article
Language:English
Subjects:
Anemia
Anemia - immunology
Anemia - therapy
Animals
Care and treatment
Cell- and Tissue-Based Therapy - methods
Gastrointestinal system
Graft vs Host Disease - immunology
Graft vs Host Disease - prevention & control
graft-versus-host-disease
GvHD
GvHD market estimate
Health aspects
Hematologic Neoplasms - immunology
Hematologic Neoplasms - therapy
Hematopoiesis - immunology
Hematopoietic Stem Cell Transplantation
hematopoietic stem cells
Humans
Immunologic Deficiency Syndromes - immunology
Immunologic Deficiency Syndromes - therapy
mesenchymal stem cells
NK cells
Recovery of Function - immunology
Stem cells
transplantation
Treg cells
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Summary:Hematopoietic stem cell transplantation is a life-saving treatment for inherited anemias, immunodeficiencies or hematologic malignancies. When using partially HLA-matched allografts, a major complication is graft-versus-host disease (GvHD). The ideal attributes of a transformational new GvHD treatment include improved survival, decreased corticosteroids, decreased antifungals, improved quality of life through decreased infections, reduced number of hospital stay days, reduced risks of developing chronic GvHD impact on lower GI tract and liver, prophylactic benefits and decreased GvHD relapses, but, in the case of cancer, without negatively impacting beneficial graft-versus-tumor effects. The current practice of hematopoietic stem cell transplantation, its incidence and its unmet medical needs are reviewed here and discussed.
ISSN:1746-0751
1746-076X
DOI:10.2217/rme.15.12