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Heterogeneous patterns of vasoreactivity in the middle cerebral and internal carotid arteries
This study compared changes in cross-sectional area (CSA) and flow (Q) between the middle cerebral artery (MCA) and the internal carotid artery (ICA) at baseline and during 5 min of hypercapnia (HC; 6% CO2) and hypocapnia (HO; hyperventilation) and quantified how these changes contribute to estimate...
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| Published in: | American journal of physiology. Heart and circulatory physiology 2015-05, Vol.308 (9), p.H1030-H1038 |
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| cites | cdi_FETCH-LOGICAL-c399t-b95a3437416f0c868a56ba49909d41026033b97ad7936240e539f9b9b5a3eebf3 |
| container_end_page | H1038 |
| container_issue | 9 |
| container_start_page | H1030 |
| container_title | American journal of physiology. Heart and circulatory physiology |
| container_volume | 308 |
| creator | Coverdale, Nicole S Lalande, Sophie Perrotta, Amanda Shoemaker, J Kevin |
| description | This study compared changes in cross-sectional area (CSA) and flow (Q) between the middle cerebral artery (MCA) and the internal carotid artery (ICA) at baseline and during 5 min of hypercapnia (HC; 6% CO2) and hypocapnia (HO; hyperventilation) and quantified how these changes contribute to estimates of cerebrovascular reactivity (CVR). Measures of MCA CSA were made using 3T magnetic resonance imaging. On a separate day, MCA flow velocity was measured with transcranial Doppler ultrasound and ICA diameters and flow velocity were measured with duplex ultrasound. Fourteen subjects (23 ± 3 yr, 7 females) participated, providing data for 11 subjects during HC and 9 subjects during HO. An increase in MCA CSA (P < 0.05) was observed within the first minute of HC. During HO, the decrease in MCA CSA (P < 0.05) was delayed until minute 4. No changes were observed in ICA CSA during HC or HO. The relative changes in QICA and QMCA were similar during HC and HO. Therefore, the MCA, but not ICA, dilates and constricts during 5 min of HC and HO, respectively. The consequent impact on QMCA significantly affects estimates of CVR, and reactivity cannot be attributed solely to changes in smaller arterioles. |
| doi_str_mv | 10.1152/ajpheart.00761.2014 |
| format | article |
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Measures of MCA CSA were made using 3T magnetic resonance imaging. On a separate day, MCA flow velocity was measured with transcranial Doppler ultrasound and ICA diameters and flow velocity were measured with duplex ultrasound. Fourteen subjects (23 ± 3 yr, 7 females) participated, providing data for 11 subjects during HC and 9 subjects during HO. An increase in MCA CSA (P < 0.05) was observed within the first minute of HC. During HO, the decrease in MCA CSA (P < 0.05) was delayed until minute 4. No changes were observed in ICA CSA during HC or HO. The relative changes in QICA and QMCA were similar during HC and HO. Therefore, the MCA, but not ICA, dilates and constricts during 5 min of HC and HO, respectively. The consequent impact on QMCA significantly affects estimates of CVR, and reactivity cannot be attributed solely to changes in smaller arterioles.</description><identifier>ISSN: 0363-6135</identifier><identifier>EISSN: 1522-1539</identifier><identifier>DOI: 10.1152/ajpheart.00761.2014</identifier><identifier>PMID: 25724496</identifier><identifier>CODEN: AJPPDI</identifier><language>eng</language><publisher>United States: American Physiological Society</publisher><subject>Adaptation, Physiological ; Adult ; Blood Flow Velocity ; Brain ; Carotid Artery, Internal - diagnostic imaging ; Carotid Artery, Internal - physiopathology ; Cerebrovascular Circulation ; Female ; Flow velocity ; Humans ; Hypercapnia - diagnostic imaging ; Hypercapnia - physiopathology ; Hypocapnia - diagnostic imaging ; Hypocapnia - physiopathology ; Magnetic Resonance Imaging ; Male ; Middle Cerebral Artery - diagnostic imaging ; Middle Cerebral Artery - physiopathology ; NMR ; Nuclear magnetic resonance ; Physiology ; Regional Blood Flow ; Time Factors ; Ultrasonic imaging ; Ultrasonography, Doppler, Duplex ; Ultrasonography, Doppler, Pulsed ; Ultrasonography, Doppler, Transcranial ; Vasoconstriction ; Vasodilation ; Veins & arteries ; Young Adult</subject><ispartof>American journal of physiology. Heart and circulatory physiology, 2015-05, Vol.308 (9), p.H1030-H1038</ispartof><rights>Copyright © 2015 the American Physiological Society.</rights><rights>Copyright American Physiological Society May 1, 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-b95a3437416f0c868a56ba49909d41026033b97ad7936240e539f9b9b5a3eebf3</citedby><cites>FETCH-LOGICAL-c399t-b95a3437416f0c868a56ba49909d41026033b97ad7936240e539f9b9b5a3eebf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25724496$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Coverdale, Nicole S</creatorcontrib><creatorcontrib>Lalande, Sophie</creatorcontrib><creatorcontrib>Perrotta, Amanda</creatorcontrib><creatorcontrib>Shoemaker, J Kevin</creatorcontrib><title>Heterogeneous patterns of vasoreactivity in the middle cerebral and internal carotid arteries</title><title>American journal of physiology. Heart and circulatory physiology</title><addtitle>Am J Physiol Heart Circ Physiol</addtitle><description>This study compared changes in cross-sectional area (CSA) and flow (Q) between the middle cerebral artery (MCA) and the internal carotid artery (ICA) at baseline and during 5 min of hypercapnia (HC; 6% CO2) and hypocapnia (HO; hyperventilation) and quantified how these changes contribute to estimates of cerebrovascular reactivity (CVR). Measures of MCA CSA were made using 3T magnetic resonance imaging. On a separate day, MCA flow velocity was measured with transcranial Doppler ultrasound and ICA diameters and flow velocity were measured with duplex ultrasound. Fourteen subjects (23 ± 3 yr, 7 females) participated, providing data for 11 subjects during HC and 9 subjects during HO. An increase in MCA CSA (P < 0.05) was observed within the first minute of HC. During HO, the decrease in MCA CSA (P < 0.05) was delayed until minute 4. No changes were observed in ICA CSA during HC or HO. The relative changes in QICA and QMCA were similar during HC and HO. Therefore, the MCA, but not ICA, dilates and constricts during 5 min of HC and HO, respectively. The consequent impact on QMCA significantly affects estimates of CVR, and reactivity cannot be attributed solely to changes in smaller arterioles.</description><subject>Adaptation, Physiological</subject><subject>Adult</subject><subject>Blood Flow Velocity</subject><subject>Brain</subject><subject>Carotid Artery, Internal - diagnostic imaging</subject><subject>Carotid Artery, Internal - physiopathology</subject><subject>Cerebrovascular Circulation</subject><subject>Female</subject><subject>Flow velocity</subject><subject>Humans</subject><subject>Hypercapnia - diagnostic imaging</subject><subject>Hypercapnia - physiopathology</subject><subject>Hypocapnia - diagnostic imaging</subject><subject>Hypocapnia - physiopathology</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Cerebral Artery - diagnostic imaging</subject><subject>Middle Cerebral Artery - physiopathology</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Physiology</subject><subject>Regional Blood Flow</subject><subject>Time Factors</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonography, Doppler, Duplex</subject><subject>Ultrasonography, Doppler, Pulsed</subject><subject>Ultrasonography, Doppler, Transcranial</subject><subject>Vasoconstriction</subject><subject>Vasodilation</subject><subject>Veins & arteries</subject><subject>Young Adult</subject><issn>0363-6135</issn><issn>1522-1539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNpdkE1LxDAQhoMo7rr6CwQJePHSNWnapDnKoq6w4EWPEtJ26mbpl0m6sP_edD88eBqGed5h5kHolpI5pWn8qDf9GrT1c0IEp_OY0OQMTcMkjmjK5DmaEsZZxClLJ-jKuQ0hJBWcXaJJnIo4SSSfoq8leLDdN7TQDQ732oe2dbir8Fa7zoIuvNkav8OmxX4NuDFlWQMuwEJudY11W4bRGApNoW3nTYnDVWANuGt0Uenawc2xztDny_PHYhmt3l_fFk-rqGBS-iiXqWYJEwnlFSkynumU5zqRksgyoSTmhLFcCl0KyXicEAjvVTKXeYgB5BWboYfD3t52PwM4rxrjCqhrvX9LUS5ElklOs4De_0M33TAeP1IZlYwINlLsQBW2c85CpXprGm13ihI12lcn-2pvX432Q-ruuHvIGyj_Mifd7Bf77oKL</recordid><startdate>20150501</startdate><enddate>20150501</enddate><creator>Coverdale, Nicole S</creator><creator>Lalande, Sophie</creator><creator>Perrotta, Amanda</creator><creator>Shoemaker, J Kevin</creator><general>American Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20150501</creationdate><title>Heterogeneous patterns of vasoreactivity in the middle cerebral and internal carotid arteries</title><author>Coverdale, Nicole S ; Lalande, Sophie ; Perrotta, Amanda ; Shoemaker, J Kevin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-b95a3437416f0c868a56ba49909d41026033b97ad7936240e539f9b9b5a3eebf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adaptation, Physiological</topic><topic>Adult</topic><topic>Blood Flow Velocity</topic><topic>Brain</topic><topic>Carotid Artery, Internal - diagnostic imaging</topic><topic>Carotid Artery, Internal - physiopathology</topic><topic>Cerebrovascular Circulation</topic><topic>Female</topic><topic>Flow velocity</topic><topic>Humans</topic><topic>Hypercapnia - diagnostic imaging</topic><topic>Hypercapnia - physiopathology</topic><topic>Hypocapnia - diagnostic imaging</topic><topic>Hypocapnia - physiopathology</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Cerebral Artery - diagnostic imaging</topic><topic>Middle Cerebral Artery - physiopathology</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Physiology</topic><topic>Regional Blood Flow</topic><topic>Time Factors</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonography, Doppler, Duplex</topic><topic>Ultrasonography, Doppler, Pulsed</topic><topic>Ultrasonography, Doppler, Transcranial</topic><topic>Vasoconstriction</topic><topic>Vasodilation</topic><topic>Veins & arteries</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Coverdale, Nicole S</creatorcontrib><creatorcontrib>Lalande, Sophie</creatorcontrib><creatorcontrib>Perrotta, Amanda</creatorcontrib><creatorcontrib>Shoemaker, J Kevin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Coverdale, Nicole S</au><au>Lalande, Sophie</au><au>Perrotta, Amanda</au><au>Shoemaker, J Kevin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heterogeneous patterns of vasoreactivity in the middle cerebral and internal carotid arteries</atitle><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle><addtitle>Am J Physiol Heart Circ Physiol</addtitle><date>2015-05-01</date><risdate>2015</risdate><volume>308</volume><issue>9</issue><spage>H1030</spage><epage>H1038</epage><pages>H1030-H1038</pages><issn>0363-6135</issn><eissn>1522-1539</eissn><coden>AJPPDI</coden><abstract>This study compared changes in cross-sectional area (CSA) and flow (Q) between the middle cerebral artery (MCA) and the internal carotid artery (ICA) at baseline and during 5 min of hypercapnia (HC; 6% CO2) and hypocapnia (HO; hyperventilation) and quantified how these changes contribute to estimates of cerebrovascular reactivity (CVR). Measures of MCA CSA were made using 3T magnetic resonance imaging. On a separate day, MCA flow velocity was measured with transcranial Doppler ultrasound and ICA diameters and flow velocity were measured with duplex ultrasound. Fourteen subjects (23 ± 3 yr, 7 females) participated, providing data for 11 subjects during HC and 9 subjects during HO. An increase in MCA CSA (P < 0.05) was observed within the first minute of HC. During HO, the decrease in MCA CSA (P < 0.05) was delayed until minute 4. No changes were observed in ICA CSA during HC or HO. The relative changes in QICA and QMCA were similar during HC and HO. Therefore, the MCA, but not ICA, dilates and constricts during 5 min of HC and HO, respectively. The consequent impact on QMCA significantly affects estimates of CVR, and reactivity cannot be attributed solely to changes in smaller arterioles.</abstract><cop>United States</cop><pub>American Physiological Society</pub><pmid>25724496</pmid><doi>10.1152/ajpheart.00761.2014</doi></addata></record> |
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| subjects | Adaptation, Physiological Adult Blood Flow Velocity Brain Carotid Artery, Internal - diagnostic imaging Carotid Artery, Internal - physiopathology Cerebrovascular Circulation Female Flow velocity Humans Hypercapnia - diagnostic imaging Hypercapnia - physiopathology Hypocapnia - diagnostic imaging Hypocapnia - physiopathology Magnetic Resonance Imaging Male Middle Cerebral Artery - diagnostic imaging Middle Cerebral Artery - physiopathology NMR Nuclear magnetic resonance Physiology Regional Blood Flow Time Factors Ultrasonic imaging Ultrasonography, Doppler, Duplex Ultrasonography, Doppler, Pulsed Ultrasonography, Doppler, Transcranial Vasoconstriction Vasodilation Veins & arteries Young Adult |
| title | Heterogeneous patterns of vasoreactivity in the middle cerebral and internal carotid arteries |
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