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Changes in the metabolic profile of pregnant ewes to an acute feed restriction in late gestation
AIM: To detect early changes in the metabolic profile of pregnant ewes subject to acute feed restriction at 130 days of gestation, and to establish indicators of risk for ovine pregnancy toxaemia (OPT) for diagnostic purposes. METHODS: Twenty Corriedale ewes with known mating dates, carrying a singl...
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| Published in: | New Zealand veterinary journal 2015-05, Vol.63 (3), p.141-146 |
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| container_title | New Zealand veterinary journal |
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| creator | Cal-Pereyra, L Benech, A González-Montaña, JR Acosta-Dibarrat, J Da Silva, S Martín, A |
| description | AIM: To detect early changes in the metabolic profile of pregnant ewes subject to acute feed restriction at 130 days of gestation, and to establish indicators of risk for ovine pregnancy toxaemia (OPT) for diagnostic purposes. METHODS: Twenty Corriedale ewes with known mating dates, carrying a single fetus, were used. Ewes were maintained on meadow grasslands and at 130 days of gestation were randomly divided in two groups of 10 ewes. The control group had ad libitum access to pasture. Ewes in the restricted group were subjected to an acute feed restriction for a maximum of 144 hours (6 days), with free access to water. From the start (0 hours) until the end of feed restriction, blood samples were collected from all ewes to monitor concentrations of cortisol, non-esterified fatty acids (NEFA), ß-hydroxybutyrate (BOHB) daily, and glucose in plasma every 6 hours; urinary pH was also measured. Every 6 hours the food restricted ewes were observed to detect clinical signs of OPT e.g. apathy, grinding teeth, empty chewing movements, head leaning against the wall, tachypnea and not drinking water. RESULTS: In food-restricted ewes, concentrations of glucose decreased and differed from control ewes from 54 to 90 hours (p |
| doi_str_mv | 10.1080/00480169.2014.971083 |
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METHODS: Twenty Corriedale ewes with known mating dates, carrying a single fetus, were used. Ewes were maintained on meadow grasslands and at 130 days of gestation were randomly divided in two groups of 10 ewes. The control group had ad libitum access to pasture. Ewes in the restricted group were subjected to an acute feed restriction for a maximum of 144 hours (6 days), with free access to water. From the start (0 hours) until the end of feed restriction, blood samples were collected from all ewes to monitor concentrations of cortisol, non-esterified fatty acids (NEFA), ß-hydroxybutyrate (BOHB) daily, and glucose in plasma every 6 hours; urinary pH was also measured. Every 6 hours the food restricted ewes were observed to detect clinical signs of OPT e.g. apathy, grinding teeth, empty chewing movements, head leaning against the wall, tachypnea and not drinking water. RESULTS: In food-restricted ewes, concentrations of glucose decreased and differed from control ewes from 54 to 90 hours (p<0.001), and 96 to 102 hours (p<0.05). Concentrations of BOHB, cortisol and NEFA increased following feed restriction and differed from control ewes after 48 to 144 hours (p<0.01). Eight of the 10 restricted ewes showed clinical signs of OPT after 102–132 hours. Mean concentrations of glucose, BOHB and cortisol differed between control and restricted ewes prior to the onset of clinical signs of OPT, after 48–96 hours of feed restriction (p<0.01). Mean gestational length, and time from birth to placental expulsion was not affected by the feed restriction. CONCLUSIONS: Our results suggest that concentrations of glucose, BOHB and cortisol in plasma may provide a precocious diagnosis of subclinical OPT, using values of 1.59 (SD 0.24) mmol/L, 2.26 (SD 1.03) mmol/L and 15.09 (SD 7.75) nmol/L, respectively. The identification of a potentially harmful metabolic imbalance could lead to the improvement of treatment success.</description><identifier>ISSN: 1176-0710</identifier><identifier>ISSN: 0048-0169</identifier><identifier>EISSN: 1176-0710</identifier><identifier>DOI: 10.1080/00480169.2014.971083</identifier><identifier>PMID: 25275560</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>3-Hydroxybutyric Acid - blood ; Animals ; blood ; Blood Glucose ; Corriedale ; cortisol ; drinking water ; Energy Metabolism - physiology ; ewes ; Fatty Acids, Nonesterified - blood ; Female ; Food Deprivation - physiology ; free fatty acids ; glucose ; grinding ; head ; mastication ; meadows ; non-esterified fatty acids ; Ovine pregnancy toxaemia ; Pregnancy ; pregnancy toxemia ; restricted feeding ; risk ; sheep ; Sheep - blood ; Sheep - physiology ; Sheep - urine ; tachypnea ; teeth ; Time Factors ; ß-hydroxybuthyrate</subject><ispartof>New Zealand veterinary journal, 2015-05, Vol.63 (3), p.141-146</ispartof><rights>2015 New Zealand Veterinary Association 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-c17b3d5b790264b83b98ca16635c98adc1437bddb62a092c6c7f661972a4ec4b3</citedby><cites>FETCH-LOGICAL-c457t-c17b3d5b790264b83b98ca16635c98adc1437bddb62a092c6c7f661972a4ec4b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25275560$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cal-Pereyra, L</creatorcontrib><creatorcontrib>Benech, A</creatorcontrib><creatorcontrib>González-Montaña, JR</creatorcontrib><creatorcontrib>Acosta-Dibarrat, J</creatorcontrib><creatorcontrib>Da Silva, S</creatorcontrib><creatorcontrib>Martín, A</creatorcontrib><title>Changes in the metabolic profile of pregnant ewes to an acute feed restriction in late gestation</title><title>New Zealand veterinary journal</title><addtitle>N Z Vet J</addtitle><description>AIM: To detect early changes in the metabolic profile of pregnant ewes subject to acute feed restriction at 130 days of gestation, and to establish indicators of risk for ovine pregnancy toxaemia (OPT) for diagnostic purposes. METHODS: Twenty Corriedale ewes with known mating dates, carrying a single fetus, were used. Ewes were maintained on meadow grasslands and at 130 days of gestation were randomly divided in two groups of 10 ewes. The control group had ad libitum access to pasture. Ewes in the restricted group were subjected to an acute feed restriction for a maximum of 144 hours (6 days), with free access to water. From the start (0 hours) until the end of feed restriction, blood samples were collected from all ewes to monitor concentrations of cortisol, non-esterified fatty acids (NEFA), ß-hydroxybutyrate (BOHB) daily, and glucose in plasma every 6 hours; urinary pH was also measured. Every 6 hours the food restricted ewes were observed to detect clinical signs of OPT e.g. apathy, grinding teeth, empty chewing movements, head leaning against the wall, tachypnea and not drinking water. RESULTS: In food-restricted ewes, concentrations of glucose decreased and differed from control ewes from 54 to 90 hours (p<0.001), and 96 to 102 hours (p<0.05). Concentrations of BOHB, cortisol and NEFA increased following feed restriction and differed from control ewes after 48 to 144 hours (p<0.01). Eight of the 10 restricted ewes showed clinical signs of OPT after 102–132 hours. Mean concentrations of glucose, BOHB and cortisol differed between control and restricted ewes prior to the onset of clinical signs of OPT, after 48–96 hours of feed restriction (p<0.01). Mean gestational length, and time from birth to placental expulsion was not affected by the feed restriction. CONCLUSIONS: Our results suggest that concentrations of glucose, BOHB and cortisol in plasma may provide a precocious diagnosis of subclinical OPT, using values of 1.59 (SD 0.24) mmol/L, 2.26 (SD 1.03) mmol/L and 15.09 (SD 7.75) nmol/L, respectively. The identification of a potentially harmful metabolic imbalance could lead to the improvement of treatment success.</description><subject>3-Hydroxybutyric Acid - blood</subject><subject>Animals</subject><subject>blood</subject><subject>Blood Glucose</subject><subject>Corriedale</subject><subject>cortisol</subject><subject>drinking water</subject><subject>Energy Metabolism - physiology</subject><subject>ewes</subject><subject>Fatty Acids, Nonesterified - blood</subject><subject>Female</subject><subject>Food Deprivation - physiology</subject><subject>free fatty acids</subject><subject>glucose</subject><subject>grinding</subject><subject>head</subject><subject>mastication</subject><subject>meadows</subject><subject>non-esterified fatty acids</subject><subject>Ovine pregnancy toxaemia</subject><subject>Pregnancy</subject><subject>pregnancy toxemia</subject><subject>restricted feeding</subject><subject>risk</subject><subject>sheep</subject><subject>Sheep - blood</subject><subject>Sheep - physiology</subject><subject>Sheep - urine</subject><subject>tachypnea</subject><subject>teeth</subject><subject>Time Factors</subject><subject>ß-hydroxybuthyrate</subject><issn>1176-0710</issn><issn>0048-0169</issn><issn>1176-0710</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqFkEFPHSEUhUnTplrtPzDK0s175Q4zMLNqmhdtm5h0oa7phYEnZgYUeDH-e3kZNd11xeXynXPIIeQE2BpYz74x1vYMxLBuGLTrQdYl_0AOAaRYsXr7-M98QL7kfM8Y74CLz-Sg6RrZdYIdkr-bOwxbm6kPtNxZOtuCOk7e0IcUnZ8sja6OdhswFGqfKlkixUDR7IqlztqRJptL8qb4GPY2E9aHallwvzkmnxxO2X59PY_I7eXFzebX6urPz9-bH1cr03ayrAxIzcdOy4E1otU910NvEITgnRl6HA20XOpx1KJBNjRGGOmEgEE22FrTan5Ezhff-u_HXU1Xs8_GThMGG3dZgZCyH0BwXtF2QU2KOSfr1EPyM6ZnBUztu1Vv3ap9t2rptspOXxN2erbju-itzAp8XwAfXEwzPsU0jarg8xSTSxiMz4r_J-JscXAYFW5TFdxeV0AwBgBNzXgBgkmRSg</recordid><startdate>20150504</startdate><enddate>20150504</enddate><creator>Cal-Pereyra, L</creator><creator>Benech, A</creator><creator>González-Montaña, JR</creator><creator>Acosta-Dibarrat, J</creator><creator>Da Silva, S</creator><creator>Martín, A</creator><general>Taylor & Francis</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150504</creationdate><title>Changes in the metabolic profile of pregnant ewes to an acute feed restriction in late gestation</title><author>Cal-Pereyra, L ; Benech, A ; González-Montaña, JR ; Acosta-Dibarrat, J ; Da Silva, S ; Martín, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-c17b3d5b790264b83b98ca16635c98adc1437bddb62a092c6c7f661972a4ec4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>3-Hydroxybutyric Acid - blood</topic><topic>Animals</topic><topic>blood</topic><topic>Blood Glucose</topic><topic>Corriedale</topic><topic>cortisol</topic><topic>drinking water</topic><topic>Energy Metabolism - physiology</topic><topic>ewes</topic><topic>Fatty Acids, Nonesterified - blood</topic><topic>Female</topic><topic>Food Deprivation - physiology</topic><topic>free fatty acids</topic><topic>glucose</topic><topic>grinding</topic><topic>head</topic><topic>mastication</topic><topic>meadows</topic><topic>non-esterified fatty acids</topic><topic>Ovine pregnancy toxaemia</topic><topic>Pregnancy</topic><topic>pregnancy toxemia</topic><topic>restricted feeding</topic><topic>risk</topic><topic>sheep</topic><topic>Sheep - blood</topic><topic>Sheep - physiology</topic><topic>Sheep - urine</topic><topic>tachypnea</topic><topic>teeth</topic><topic>Time Factors</topic><topic>ß-hydroxybuthyrate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cal-Pereyra, L</creatorcontrib><creatorcontrib>Benech, A</creatorcontrib><creatorcontrib>González-Montaña, JR</creatorcontrib><creatorcontrib>Acosta-Dibarrat, J</creatorcontrib><creatorcontrib>Da Silva, S</creatorcontrib><creatorcontrib>Martín, A</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>New Zealand veterinary journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cal-Pereyra, L</au><au>Benech, A</au><au>González-Montaña, JR</au><au>Acosta-Dibarrat, J</au><au>Da Silva, S</au><au>Martín, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in the metabolic profile of pregnant ewes to an acute feed restriction in late gestation</atitle><jtitle>New Zealand veterinary journal</jtitle><addtitle>N Z Vet J</addtitle><date>2015-05-04</date><risdate>2015</risdate><volume>63</volume><issue>3</issue><spage>141</spage><epage>146</epage><pages>141-146</pages><issn>1176-0710</issn><issn>0048-0169</issn><eissn>1176-0710</eissn><abstract>AIM: To detect early changes in the metabolic profile of pregnant ewes subject to acute feed restriction at 130 days of gestation, and to establish indicators of risk for ovine pregnancy toxaemia (OPT) for diagnostic purposes. METHODS: Twenty Corriedale ewes with known mating dates, carrying a single fetus, were used. Ewes were maintained on meadow grasslands and at 130 days of gestation were randomly divided in two groups of 10 ewes. The control group had ad libitum access to pasture. Ewes in the restricted group were subjected to an acute feed restriction for a maximum of 144 hours (6 days), with free access to water. From the start (0 hours) until the end of feed restriction, blood samples were collected from all ewes to monitor concentrations of cortisol, non-esterified fatty acids (NEFA), ß-hydroxybutyrate (BOHB) daily, and glucose in plasma every 6 hours; urinary pH was also measured. Every 6 hours the food restricted ewes were observed to detect clinical signs of OPT e.g. apathy, grinding teeth, empty chewing movements, head leaning against the wall, tachypnea and not drinking water. RESULTS: In food-restricted ewes, concentrations of glucose decreased and differed from control ewes from 54 to 90 hours (p<0.001), and 96 to 102 hours (p<0.05). Concentrations of BOHB, cortisol and NEFA increased following feed restriction and differed from control ewes after 48 to 144 hours (p<0.01). Eight of the 10 restricted ewes showed clinical signs of OPT after 102–132 hours. Mean concentrations of glucose, BOHB and cortisol differed between control and restricted ewes prior to the onset of clinical signs of OPT, after 48–96 hours of feed restriction (p<0.01). Mean gestational length, and time from birth to placental expulsion was not affected by the feed restriction. CONCLUSIONS: Our results suggest that concentrations of glucose, BOHB and cortisol in plasma may provide a precocious diagnosis of subclinical OPT, using values of 1.59 (SD 0.24) mmol/L, 2.26 (SD 1.03) mmol/L and 15.09 (SD 7.75) nmol/L, respectively. The identification of a potentially harmful metabolic imbalance could lead to the improvement of treatment success.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>25275560</pmid><doi>10.1080/00480169.2014.971083</doi><tpages>6</tpages></addata></record> |
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| ispartof | New Zealand veterinary journal, 2015-05, Vol.63 (3), p.141-146 |
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| subjects | 3-Hydroxybutyric Acid - blood Animals blood Blood Glucose Corriedale cortisol drinking water Energy Metabolism - physiology ewes Fatty Acids, Nonesterified - blood Female Food Deprivation - physiology free fatty acids glucose grinding head mastication meadows non-esterified fatty acids Ovine pregnancy toxaemia Pregnancy pregnancy toxemia restricted feeding risk sheep Sheep - blood Sheep - physiology Sheep - urine tachypnea teeth Time Factors ß-hydroxybuthyrate |
| title | Changes in the metabolic profile of pregnant ewes to an acute feed restriction in late gestation |
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