A paper based microfluidic device for easy detection of uric acid using positively charged gold nanoparticles

A paper based microfluidic device is fabricated that can rapidly detect very low concentrations of uric acid (UA) using 3,5,3',5'-tetramethyl benzidine (TMB), H2O2 and positively charged gold nanoparticles ((+)AuNPs). In the presence of (+)AuNPs, H2O2 reacts with TMB to produce a bluish-gr...

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Bibliographic Details
Published in:Analyst (London) 2015-03, Vol.140 (6), p.1817-1821
Main Authors: Kumar, Anand, Hens, Abhiram, Arun, Ravi Kumar, Chatterjee, Monosree, Mahato, Kuldeep, Layek, Keya, Chanda, Nripen
Format: Article
Language:English
Subjects:
Benzidines - chemistry
Charging
Chromogenic Compounds - chemistry
Color
Colorimetry - instrumentation
Colour
Devices
Equipment Design
Gold
Gold - chemistry
Hydrogen Peroxide - chemistry
Limit of Detection
Metal Nanoparticles - chemistry
Microfluidic Analytical Techniques - instrumentation
Microfluidics
Nanoparticles
Uric acid
Uric Acid - analysis
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Summary:A paper based microfluidic device is fabricated that can rapidly detect very low concentrations of uric acid (UA) using 3,5,3',5'-tetramethyl benzidine (TMB), H2O2 and positively charged gold nanoparticles ((+)AuNPs). In the presence of (+)AuNPs, H2O2 reacts with TMB to produce a bluish-green colour which becomes colourless on reaction with UA. This colorimetric method can detect as low as 8.1 ppm of UA within
ISSN:0003-2654
1364-5528
DOI:10.1039/c4an02333a