Cytotoxicity, DNA damage, and apoptosis induced by titanium dioxide nanoparticles in human non-small cell lung cancer A549 cells

Concerns about the risk of titanium dioxide nanoparticles (TiO₂NPs) to human health and environment are gradually increasing due to their wide range of applications. In this study, cytotoxicity, DNA damage, and apoptosis induced by TiO₂NPs (5 nm) in A549 cells were investigated. The 3-(4,5-dimethylt...

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Bibliographic Details
Published in:Environmental science and pollution research international 2015-04, Vol.22 (7), p.5519-5530
Main Authors: Wang, Yurong, Cui, Haiyan, Zhou, Jiaping, Li, Fengjuan, Wang, Jinju, Chen, Mianhua, Liu, Qingdai
Format: Article
Language:English
Subjects:
Air pollution
Analysis of Variance
Apoptosis
Apoptosis - drug effects
Aquatic Pollution
Assaying
Atmospheric Protection/Air Quality Control/Air Pollution
Bioassays
Carcinogens, Environmental - toxicity
caspase-3
caspase-9
Cell culture
Cell Line, Tumor
cell proliferation
Comet Assay
Cytotoxicity
Damage
Deoxyribonucleic acid
DNA
DNA Damage
Dose-Response Relationship, Drug
Earth and Environmental Science
Ecotoxicology
Environment
Environmental changes
Environmental Chemistry
Environmental Health
Environmental science
Flow Cytometry
G2 Phase Cell Cycle Checkpoints - drug effects
Health
Human
human health
Humans
Indoles
Laboratories
Lung cancer
lung neoplasms
membrane potential
messenger RNA
Metal Nanoparticles - toxicity
Micronucleus Tests
mitochondrial membrane
Nanoparticles
quantitative analysis
quantitative polymerase chain reaction
Real-Time Polymerase Chain Reaction
Research Article
reverse transcriptase polymerase chain reaction
risk
Staining
Studies
Tetrazolium Salts
Thiazoles
Titanium
Titanium - toxicity
Titanium dioxide
Titanium oxide powders
Toxicity
Waste Water Technology
Water Management
Water Pollution Control
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Summary:Concerns about the risk of titanium dioxide nanoparticles (TiO₂NPs) to human health and environment are gradually increasing due to their wide range of applications. In this study, cytotoxicity, DNA damage, and apoptosis induced by TiO₂NPs (5 nm) in A549 cells were investigated. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays revealed the time- and concentration-dependent cytotoxic effects of TiO₂NPs in a concentration range of 50 to 200 μg/mL. A statistically significant (p 
ISSN:0944-1344
1614-7499
DOI:10.1007/s11356-014-3717-7