Fluorescence spectra of blood and urine for cervical cancer detection

In the current study, the fluorescence emission spectra (FES) and Stokes shift spectra (SSS) of blood and urine samples of cervical cancer patients were obtained and compared to those of normal controls. Both spectra showed that the relative intensity of biomolecules such as porphyrin, collagen, Nic...

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Bibliographic Details
Published in:Journal of biomedical optics 2012-09, Vol.17 (9), p.98001-1-098001-3
Main Authors: Masilamani, Vadivel, Alsalhi, Mohamad Saleh, Vijmasi, Trinka, Govindarajan, Kanaganaj, Rathan Rai, Ram, Atif, Muhammad, Prasad, Saradh, Aldwayyan, Abdullah S
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - blood
Biomarkers, Tumor - urine
Biomolecules
Blood
Cancer
Diagnosis
Female
Fluorescence
Humans
Patients
Reproducibility of Results
Sensitivity and Specificity
Spectra
Spectrometry, Fluorescence - methods
Urine
Uterine Cervical Neoplasms - diagnosis
Uterine Cervical Neoplasms - metabolism
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Summary:In the current study, the fluorescence emission spectra (FES) and Stokes shift spectra (SSS) of blood and urine samples of cervical cancer patients were obtained and compared to those of normal controls. Both spectra showed that the relative intensity of biomolecules such as porphyrin, collagen, Nicotinamide adenine dinucleotide, and flavin were quite out of proportion in cervical cancer patients. The biochemical mechanism for the elevation of these fluorophores is not yet definitive; nevertheless, these biomolecules could serve as tumor markers for diagnosis, screening, and follow-up of cervical cancers. To the best of our knowledge, this is the first report on FES and SSS of blood and urine of cervical cancer patients to give a sensitivity of 80% and specificity of 78%.
ISSN:1083-3668
1560-2281
DOI:10.1117/1.JBO.17.9.098001