Hybrid hyaluronic acid hydrogel/poly(ɛ-caprolactone) scaffold provides mechanically favorable platform for cartilage tissue engineering studies

Hybrid scaffolds for cartilage tissue engineering provide the potential for high stiffness properties in tension and compression while exhibiting the viscoelastic response found in hydrogels and native cartilage tissue. We investigate the impact of a hybrid scaffold fabricated from a hyaluronic acid...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part A 2014-09, Vol.102 (9), p.2918-2926
Main Authors: Mintz, Benjamin R., Cooper Jr, James A.
Format: Article
Language:English
Subjects:
Animals
articular cartilage
Biological and medical sciences
Biotechnology
Cartilage
Cartilage - cytology
Cattle
Cells, Cultured
Chondrocytes - cytology
Compressing
Controllers
dynamic mechanical analysis
Fundamental and applied biological sciences. Psychology
Health. Pharmaceutical industry
Human
Hyaluronic acid
Hyaluronic Acid - chemistry
Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry
Hydrogels
Industrial applications and implications. Economical aspects
Medical sciences
Miscellaneous
Platforms
poly(ɛ-caprolactone)
Polyesters - chemistry
Programmable logic devices
Scaffolds
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Technology. Biomaterials. Equipments
tissue engineering
Tissue Engineering - methods
Tissue Scaffolds - chemistry
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Summary:Hybrid scaffolds for cartilage tissue engineering provide the potential for high stiffness properties in tension and compression while exhibiting the viscoelastic response found in hydrogels and native cartilage tissue. We investigate the impact of a hybrid scaffold fabricated from a hyaluronic acid (HA)‐based hydrogel combined with porous poly(ε‐caprolactone) (PCL) material formed by a particulate leaching method to study dedifferentiated chondrocyte response. The material properties of the hybrid scaffold showed mean Young's moduli in tension which were similar to human articular cartilage but not statistically different between the hybrid and porous PCL scaffolds at 2.02 and 2.07 MPa, respectively. For both the hybrid and porous PCL control scaffolds in compression at low loading frequencies (
ISSN:1549-3296
1552-4965
DOI:10.1002/jbm.a.34957