A flexible lab-on-a-chip for the synthesis and magnetic separation of magnetite decorated with gold nanoparticles

Magnetite decorated with gold nanoparticles (Fe3O4-AuNPs) is a ferrimagnetic material with unprecedented applications in immunosensors, as a contrast agent for imaging diagnosis, and for the photothermal ablation of tumor cells. Here, we show the preparation of controlled amounts of Fe3O4-AuNPs with...

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Bibliographic Details
Published in:Lab on a chip 2015-04, Vol.15 (8), p.1835-1841
Main Authors: Cabrera, Flávio C, Melo, Antonio F A A, de Souza, João C P, Job, Aldo E, Crespilho, Frank N
Format: Article
Language:English
Subjects:
Decoration
Ferrimagnetic materials
Gold
Magnetic separation
Magnetite
Nanoparticles
Solvents
Surfactants
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Summary:Magnetite decorated with gold nanoparticles (Fe3O4-AuNPs) is a ferrimagnetic material with unprecedented applications in immunosensors, as a contrast agent for imaging diagnosis, and for the photothermal ablation of tumor cells. Here, we show the preparation of controlled amounts of Fe3O4-AuNPs without organic solvents, surfactants, or heat treatment. For this, we have developed a customized natural-rubber-based microfluidic device (NRMD) as a flexible lab-on-a-chip for the decoration of Fe3O4 with AuNPs. With a novel NRMD configuration, monodisperse Fe3O4-NPs (ϕ = 10 nm) decorated with AuNPs (ϕ = 4 nm) were readily obtained. The AuNPs were homogenous in terms of their size and their distribution on the Fe3O4-NP surfaces. Furthermore, the lab-on-a-chip was projected with an internal system for magnetic separation, an innovation in terms of aqueous/carrier phase separation. Finally, the nanomaterials produced with this NRMD are free of organic solvents and surfactants, allowing them to be used directly for medical applications.
ISSN:1473-0197
1473-0189
DOI:10.1039/c4lc01483a