Ligation of anti-cancer drugs to self-assembling ultrashort peptides by click chemistry for localized therapy

Self-assembling ultrashort peptides from aliphatic amino acids were functionalized with platinum anti-cancer drugs by click chemistry. Oxaliplatin-derived hybrid peptide hydrogels with up to 40% drug loading were tested for localized breast cancer therapy. Stably injected gels showed significant tum...

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Bibliographic Details
Published in:Chemical science (Cambridge) 2014-01, Vol.5 (2), p.625-630
Main Authors: Reithofer, Michael R, Chan, Kiat-Hwa, Lakshmanan, Anupama, Lam, Dang Hoang, Mishra, Archana, Gopalan, Began, Joshi, Mangesh, Wang, Shu, Hauser, Charlotte AE
Format: Article
Language:English
Subjects:
Aliphatic compounds
Amino acids
Drugs
Hydrogels
Peptides
Platinum
Therapy
Tolerances
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Summary:Self-assembling ultrashort peptides from aliphatic amino acids were functionalized with platinum anti-cancer drugs by click chemistry. Oxaliplatin-derived hybrid peptide hydrogels with up to 40% drug loading were tested for localized breast cancer therapy. Stably injected gels showed significant tumor growth inhibition in mice and a better tolerance compared to the free platinum drug.
ISSN:2041-6520
2041-6539
DOI:10.1039/c3sc51930a