Plasma treatment of electrospun PCL random nanofiber meshes (NFMs) for biological property improvement

In this article, the plasma surface modification effects on the chemical, mechanical, and biological properties of electrospun poly (ε‐caprolactone) (PCL) random nanofiber meshes (NFMs) were investigated by adjusting plasma chemistry, that is, using glow discharges of N2+H2, NH3+O2, and Ar+O2 gas mi...

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Published in:Journal of biomedical materials research. Part A 2013-04, Vol.101A (4), p.963-972
Main Authors: Yan, D., Jones, J., Yuan, X.Y., Xu, X.H., Sheng, J., Lee, J.C.-M., Ma, G.Q., Yu, Q.S.
Format: Article
Language:English
Subjects:
Animals
Biocompatible Materials - chemical synthesis
Biocompatible Materials - chemistry
Biocompatible Materials - pharmacology
Biological
Biological and medical sciences
Biomedical materials
Cell Adhesion - drug effects
cell culture
Cell Line
Contact angle
Controllers
Electrospinning
Glow discharges
Materials Testing
Medical sciences
Mice
Nanofibers - chemistry
Nanostructure
Osteoblasts - cytology
Osteoblasts - metabolism
plasma treatment
poly (ε-caprolactone)
Polyesters - chemistry
Programmable logic devices
random nanofiber meshes
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Technology. Biomaterials. Equipments
Tensile tests
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Summary:In this article, the plasma surface modification effects on the chemical, mechanical, and biological properties of electrospun poly (ε‐caprolactone) (PCL) random nanofiber meshes (NFMs) were investigated by adjusting plasma chemistry, that is, using glow discharges of N2+H2, NH3+O2, and Ar+O2 gas mixtures. The surface property changes of electrospun PCL NFMs after those plasma treatments were examined by water contact angle measurements and X‐ray photoelectron spectroscopy. The experimental results showed that the plasma treatments introduced polar groups onto the surfaces and thus increased the surface hydrophilicity. From tensile test data, plasma treatment had limited effect on the mechanical properties of PCL random NFMs. The biological properties of the plasma‐treated PCL NFMs were examined by cell proliferation assays using mouse osteoblast cells (MC3T3‐E1). It was found that the plasma‐treated PCL NFMs gave a higher proliferation rate and improved cell adhesion properties as compared with the untreated controls. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.
ISSN:1549-3296
1552-4965
DOI:10.1002/jbm.a.34398