Polar organic solvents accelerate the rate of DNA strand replacement reaction

Herein, we report a novel strategy to accelerate the rate of DNA strand replacement reaction (DSRR) by polar organic solvents. DSRR plays a vital role in DNA nanotechnology but prolonged reaction time limits its further advancement. That is why it is extremely important to speed up the rate of DSRR....

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Bibliographic Details
Published in:Analyst (London) 2015-03, Vol.140 (6), p.2023-2028
Main Authors: Zhang, Tianchi, Shang, Chunli, Duan, Ruixue, Hakeem, Abdul, Zhang, Zhenyu, Lou, Xiaoding, Xia, Fan
Format: Article
Language:English
Subjects:
Acceleration
Buffers
Deoxyribonucleic acid
DNA - chemistry
Nanotechnology
Nucleic Acid Conformation
Organic Chemicals - chemistry
Rate constants
Reaction time
Solvents
Solvents - chemistry
Spectrometry, Fluorescence
Strands
Strategy
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Summary:Herein, we report a novel strategy to accelerate the rate of DNA strand replacement reaction (DSRR) by polar organic solvents. DSRR plays a vital role in DNA nanotechnology but prolonged reaction time limits its further advancement. That is why it is extremely important to speed up the rate of DSRR. In this work, we introduce different polar organic solvents in both simple and complicated DSRR systems and observe that the rate constant is much more than in aqueous buffer. The rate acceleration of DSRR by polar organic solvents is very obvious and we believe that this strategy will extend the application of DNA nanotechnology in future.
ISSN:0003-2654
1364-5528
DOI:10.1039/c4an02302a