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Poly(γ-glutamic acid) induced homogeneous mineralization of the poly(ethylene glycol)-co-2-hydroxyethyl methacrylate cryogel for potential application in bone tissue engineering
Methacrylated poly(γ-glutamic acid) (mPGA) was introduced to the spongy poly(ethylene glycol)- co -2-hydroxyethyl methacrylate (PEG-HEMA) cryogels. A suitable amount (
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Published in: | RSC advances 2015-01, Vol.5 (26), p.20227-20233 |
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cites | cdi_FETCH-LOGICAL-c330t-bee28ed05fecd4c97f09d1409aa45c874a1859a67106cba4a937f184fc13a36e3 |
container_end_page | 20233 |
container_issue | 26 |
container_start_page | 20227 |
container_title | RSC advances |
container_volume | 5 |
creator | Liu, Chuntao Liu, Xin Quan, Changyun Li, Xiaoqiong Chen, Chaozhu Kang, Hua Hu, Weikang Jiang, Qing Zhang, Chao |
description | Methacrylated poly(γ-glutamic acid) (mPGA) was introduced to the spongy poly(ethylene glycol)-
co
-2-hydroxyethyl methacrylate (PEG-HEMA) cryogels. A suitable amount ( |
doi_str_mv | 10.1039/C4RA15893H |
format | article |
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co
-2-hydroxyethyl methacrylate (PEG-HEMA) cryogels. A suitable amount (<0.1% w/v) of poly(γ-glutamic acid) (γ-PGA) in cryogels was found to promote homogeneous mineralization, while higher concentration of γ-PGA inhibited the mineralization. The deposited minerals mainly consisted of hydroxyapatite, carbonated apatite, and calcium phosphate, and were independent on the concentration of γ-PGA. The mineralized cryogels can support adhesion, viability, and migration of rat bone marrow stromal cells (rMSCs). The γ-PGA/HEMA-PEGDA cryogels showed their great potential as promising scaffolding materials in bone tissue engineering.</abstract><doi>10.1039/C4RA15893H</doi><tpages>7</tpages></addata></record> |
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source | Royal Society of Chemistry Journals |
subjects | Adhesion Apatite Biomedical materials Bones Calcium phosphate Migration Mineralization Tissue engineering |
title | Poly(γ-glutamic acid) induced homogeneous mineralization of the poly(ethylene glycol)-co-2-hydroxyethyl methacrylate cryogel for potential application in bone tissue engineering |
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