Preparation of chitosan/mesoporous silica nanoparticle composite hydrogels for sustained co-delivery of biomacromolecules and small chemical drugs

We have developed composite hydrogels of chitosan (CS) and mesoporous silica nanoparticles (MSNs) in this study. The gelation rate, gel strength, drug delivery behavior and chondrocyte proliferation properties were investigated. The introduction of MSNs into CS accelerated the gelation process at bo...

Full description

Saved in:
Bibliographic Details
Published in:Science and technology of advanced materials 2013-08, Vol.14 (4), p.045005-9
Main Authors: Zhu, Min, Zhu, Yufang, Zhang, Lingxia, Shi, Jianlin
Format: Article
Language:English
Subjects:
Body temperature
Cartilage
cartilage regeneration
Chitosan
Culture
Drug delivery systems
Drugs
Gelation
Gentamicin
Hydrogels
mesoporous silica nanoparticles
Modulus of elasticity
Nanoparticles
Nanostructure
Regeneration
Serum albumin
Silicon dioxide
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We have developed composite hydrogels of chitosan (CS) and mesoporous silica nanoparticles (MSNs) in this study. The gelation rate, gel strength, drug delivery behavior and chondrocyte proliferation properties were investigated. The introduction of MSNs into CS accelerated the gelation process at body temperature and also increased the elastic modulus G′ from 1000 to 1800 Pa. When we used gentamicin (GS) and bovine serum albumin (BSA) as model small chemical drugs and biomacromolecules, respectively, the CS/MSN hydrogels released GS and BSA in a sustained manner simultaneously, but the CS hydrogels only showed sustained BSA release. Furthermore, in vitro chondrocyte culture showed that the CS/MSN composite hydrogels indeed performed much better in supporting chondrocyte growth and maintaining chondrocytic phenotype compared to the CS hydrogels. Therefore, the results suggest that the CS/MSN composite hydrogels can be potentially very useful for cartilage regeneration.
ISSN:1468-6996
1878-5514
DOI:10.1088/1468-6996/14/4/045005