Photoembossing of surface relief structures in polymer films for biomedical applications

Photoembossing is a technique used to create relief structures using a patterned contact photo-mask exposure and a thermal development step. Typically, the photopolymer consists of a polymer binder and a monomer in a 1/1 ratio together with a photo-initiator, which results in a solid and non-tacky m...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2014-02, Vol.102 (2), p.214-220
Main Authors: Hughes-Brittain, Nanayaa F., Qiu, Lin, Wang, Wen, Peijs, Ton, Bastiaansen, Cees W.M.
Format: Article
Language:English
Subjects:
Acrylic Resins - chemistry
Alignment
Binders
Biological and medical sciences
Biomedical materials
Cell Adhesion
cell-material interactions
Human Umbilical Vein Endothelial Cells - cytology
Human Umbilical Vein Endothelial Cells - metabolism
Humans
Materials research
Materials science
Materials Testing
Medical sciences
Membranes, Artificial
Monomers
Photochemical Processes
Photopolymers
polymer
Polymethyl methacrylates
surface modification
Surface Properties
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgical implants
Technology. Biomaterials. Equipments
Texture
Tissue Engineering - methods
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Summary:Photoembossing is a technique used to create relief structures using a patterned contact photo-mask exposure and a thermal development step. Typically, the photopolymer consists of a polymer binder and a monomer in a 1/1 ratio together with a photo-initiator, which results in a solid and non-tacky material at room temperature. Here, new mixtures for photoembossing are presented which are potentially biocompatible. Poly(methyl methacrylate) is used as a polymer binder and two different acrylate monomers trimethylolpropane ethoxylate triacrylate (TPETA) and dipentaerythritol penta-/hexa-acrylate (DPPHA) are tested. PMMA-TPETA had a higher surface relief features. Biocompatibility is evaluated by culturing human umbilical vein endothelial cells (HUVECs) on films of these photopolymer blends. PMMA with TPETA and PMMA-DPPHA films showed enhanced cell adhesion compared to PMMA. The cells also showed alignment on surface textured films with the highest degree of alignment on films with 20 μm pitch and 2 μm height. This study shows that photoembossing is a feasible method to produce surface textures on films that can be adopted in the field of tissue engineering to promote cell adhesion and alignment.
ISSN:1552-4973
1552-4981
DOI:10.1002/jbm.b.32997