Effects of model Maillard compounds on bone characteristics and functionality

• Published in: Journal of the science of food and agriculture 2013-08, Vol.93 (11), p.2816-2821
• Main Authors: Roncero-Ramos, Irene, Delgado-Andrade, Cristina, Rufián-Henares, José Ángel, Carballo, José, Navarro, M Pilar
• Format: Article
• Language: English
• Subjects: advanced glycation end-products; Animals; Arginine - analogs & derivatives; Arginine - chemistry; Arginine - metabolism; Biochemistry; Biomarkers; Biomechanical Phenomena; Biomechanics; Bone and Bones - chemistry; Bone and Bones - drug effects; Bone and Bones - physiology; bone functionality; Bone Resorption - chemically induced; Bones; Collagen Type I - metabolism; Collagens; Density; DEXA; Diet; Diets; Female; Femur; Foods; Glucose - chemistry; Glycation End Products, Advanced - pharmacology; Lysine - analogs & derivatives; Lysine - chemistry; Lysine - metabolism; Maillard Reaction; Materials requirement planning; Mechanical properties; model Maillard reaction products; pentosidine; Peptides; physical features; Physical properties; Rats; Rats, Wistar; Rodents
• ISSN: 0022-5142; 1097-0010
• DOI: 10.1002/jsfa.6107

Background Physical and biomechanical properties of bone can be affected by non‐enzymatic crosslinks, which are implicated in bone pathologies such as osteoporosis. The purpose of this study was to analyse the effects of the consumption of model Maillard reaction product (MRP) from glucose–lysine heated for 90 min at 150 °C (GL90) on bone composition and features. Rats were fed either a control diet or a diet containing 30 g kg−1 GL90 for 88 days. Food consumption and the animals' body weights were monitored. After sacrifice, the femur, pelvic bone and tibia were removed for analysis of their composition and physical and biomechanical properties. Results The organic matrix of the femur and the density of the pelvic bone decreased after MRP intake, whereas pentosidine content increased greatly with respect to the control group (41.7 ± 9.9 vs 171.4 ± 3.3 mmol mol−1 collagen). The rising level of C‐telopeptide degradation products from type I collagen (β‐CTX) suggested a possible situation of increased bone resorption and/or higher turnover. Conclusion In conjunction, the detrimental effect on the organic matrix, the situation of higher resorption and/or bone turnover indicated by the β‐CTX values and the high pentosidine content in bone provoked negative consequences on certain mechanical properties such as the ability to withstand force and absorb energy without failure. © 2013 Society of Chemical Industry