Assessment of diffusion-weighted imaging for characterizing focal liver lesions

• Published in: Clinical imaging 2015-03, Vol.39 (2), p.278-284
• Main Authors: Parsai, Arman, Zerizer, Imene, Roche, Oran, Gkoutzios, Panos, Miquel, Marc E
• Format: Article
• Language: English
• Subjects: Abscess - diagnosis; Adenoma - diagnosis; Assessments; Benign; Bile Duct Neoplasms - diagnosis; Bile Ducts, Intrahepatic - pathology; Carcinoma, Hepatocellular - diagnosis; Cholangiocarcinoma - diagnosis; Cysts; Cysts - diagnosis; Diagnosis, Differential; Diffusion; Diffusion coefficient; Diffusion Magnetic Resonance Imaging - methods; Diffusion-weighted imaging (DWI); Focal liver lesions; Focal Nodular Hyperplasia - diagnosis; Hamartoma - diagnosis; Hemangioma - diagnosis; Humans; Imaging; Lesions; Liver; Liver Diseases - diagnosis; Liver Neoplasms - diagnosis; Malignant; Metastasis; MRI; Neoplasms, Second Primary; NMR; Nuclear magnetic resonance; Patients; Radiology; Standard deviation; Studies; Thresholds; Tumors
• ISSN: 0899-7071; 1873-4499
• DOI: 10.1016/j.clinimag.2014.09.016

Abstract In 150 patients, 153 hepatic lesions (39 metastases, 27 hemangiomas, 26 hepatocellular carcinomas, 25 cysts, 15 adenomas, 8 focal nodular hyperplasias, 5 abscesses, 4 hamartomas, and 4 cholangiocarcinomas) were evaluated during a 24-month period. Apparent diffusion coefficient (ADC) values of benign lesions (1.994×10 − 3 mm2 s − 1 ) were significantly higher than ADC values of malignant lesions (1.070×10 − 3 mm2 s − 1 ). Mean ADC value for solid benign lesions (1.143×10 − 3 mm2 s − 1 ± 0.214×10 − 3 mm2 s − 1 ) was not significantly different from malignant lesions. ADC values did not allow differentiating malignant from benign solid lesions (area under the curve=0.61). ADC cutoff value threshold of 1.6×10 − 3 mm2 s − 1 yielded higher accuracy for differentiating benign from malignant lesions.