Metabolism of the designer drug α-pyrrolidinobutiophenone (α-PBP) in humans: Identification and quantification of the phase I metabolites in urine

Highlights • α-PBP and its phase I metabolites were identified/quantified in α-PBP users’ urine. • Metabolic pathways of α-PBP were reduction of ketone and oxidation of pyrrolidine. • Metabolism of α-PBP was discussed compared to that of other cathinones.

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Bibliographic Details
Published in:Forensic science international 2015-04, Vol.249, p.181-188
Main Authors: Matsuta, Shuntaro, Shima, Noriaki, Kamata, Hiroe, Kakehashi, Hidenao, Nakano, Shihoko, Sasaki, Keiko, Kamata, Tooru, Nishioka, Hiroshi, Miki, Akihiro, Katagi, Munehiro, Zaitsu, Kei, Sato, Takako, Tsuchihashi, Hitoshi, Suzuki, Koichi
Format: Article
Language:English
Subjects:
Aliphatic compounds
Cathinone
Chains
Chromatography, Liquid
Designer Drugs - chemistry
Drugs
Gas Chromatography-Mass Spectrometry
GC–MS
Human phase I metabolism
Humans
LC–MS/MS
Metabolism
Metabolites
Oxidation
Pathology
Propiophenones - chemistry
Propiophenones - urine
Pyrrolidines - chemistry
Pyrrolidines - urine
Reduction
Rings (mathematics)
Tandem Mass Spectrometry
Urine
α-PBP
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Description
Summary:Highlights • α-PBP and its phase I metabolites were identified/quantified in α-PBP users’ urine. • Metabolic pathways of α-PBP were reduction of ketone and oxidation of pyrrolidine. • Metabolism of α-PBP was discussed compared to that of other cathinones.
ISSN:0379-0738
1872-6283
DOI:10.1016/j.forsciint.2015.02.004