Adding MgO nanoparticles to hydroxyapatite–PLLA nanocomposites for improved bone tissue engineering applications

[Display omitted] Magnesium plays an important role in the body, mediating cell–extracellular matrix interactions and bone apatite structure and density. This study investigated, for the first time, the effects of adding magnesium oxide (MgO) nanoparticles to poly (l-lactic acid) (PLLA) and to hydro...

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Bibliographic Details
Published in:Acta biomaterialia 2015-03, Vol.14, p.175-184
Main Authors: Hickey, Daniel J., Ercan, Batur, Sun, Linlin, Webster, Thomas J.
Format: Article
Language:English
Subjects:
Biocompatibility
Biomedical materials
Bone and Bones - drug effects
Bone and Bones - physiology
Bones
Cell Adhesion - drug effects
Cell Proliferation - drug effects
Cells, Cultured
Durapatite - pharmacology
Humans
Hydrogen-Ion Concentration
Hydroxyapatite
Lactic Acid - pharmacology
Magnesium
Magnesium oxide
Magnesium Oxide - pharmacology
Microscopy, Atomic Force
Nanocomposites
Nanocomposites - chemistry
Nanocomposites - ultrastructure
Nanoparticles
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Nanotechnology
Orthopedic
Osteoblasts
Osteoblasts - cytology
Osteoblasts - drug effects
Osteoblasts - ultrastructure
Polyesters
Polymers - pharmacology
Spectroscopy, Fourier Transform Infrared
Surgical implants
Tissue Engineering - methods
X-Ray Diffraction
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Summary:[Display omitted] Magnesium plays an important role in the body, mediating cell–extracellular matrix interactions and bone apatite structure and density. This study investigated, for the first time, the effects of adding magnesium oxide (MgO) nanoparticles to poly (l-lactic acid) (PLLA) and to hydroxyapatite (HA) nanoparticle–PLLA composites for orthopedic tissue engineering applications. Results showed that MgO nanoparticles significantly enhanced osteoblast adhesion and proliferation on HA–PLLA nanocomposites while maintaining mechanical properties (Young’s modulus ∼1000MPa) suitable for cancellous bone applications. Additionally, osteoblasts (or bone-forming cells) cultured in the supernatant of degrading nanocomposites showed improved proliferation in the presence of magnesium, indicating that the increased alkalinity of solutions containing MgO nanocomposites had no toxic effects towards cells. These results together indicated the promise of further studying MgO nanoparticles as additive materials to polymers to enhance the integration of implanted biomaterials with bone.
ISSN:1742-7061
1878-7568
DOI:10.1016/j.actbio.2014.12.004