Towards clinical application of biomechanical tools for the prediction of fracture risk in metastatic bone disease

Abstract Current clinical practice lacks an accurate predictor for the pathological fracture risk in metastatic bone disease, but biomechanical tools are under development to improve these predictions. In this paper we explain the limitations of currently used clinical guidelines and provide an over...

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Bibliographic Details
Published in:Journal of biomechanics 2015-03, Vol.48 (5), p.761-766
Main Authors: Derikx, Loes C, Verdonschot, Nico, Tanck, Esther
Format: Article
Language:English
Subjects:
Biomechanical Phenomena
Biomechanics
Bone diseases
Bone Neoplasms - complications
Bones
Cancer
Cancer therapies
Clinical medicine
Disease control
Femur
Fracture mechanics
Fracture risk
Fractures
Fractures, Bone - etiology
Guidelines
Humans
Load
Mathematical models
Metastasis
Metastatic lesions
Older people
Osteoporosis
Pain
Patients
Physical Medicine and Rehabilitation
Prediction
Risk
Risk assessment
Studies
Surgery
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Summary:Abstract Current clinical practice lacks an accurate predictor for the pathological fracture risk in metastatic bone disease, but biomechanical tools are under development to improve these predictions. In this paper we explain the limitations of currently used clinical guidelines and provide an overview of more objective and quantitative approaches that have been proposed for fracture risk assessment in metastatic bone disease. Currently, such mechanical models are as sensitive and specific as clinical guidelines, but there are a number of opportunities to further improve their predictive capacity. Hence, they are a promising tool to decrease the numbers of over- and undertreated patients.
ISSN:0021-9290
1873-2380
DOI:10.1016/j.jbiomech.2014.12.017