Towards hybrid biocompatible magnetic rHuman serum albumin-based nanoparticles: use of ultra-small (CeL sub(n)) super(3/4+) cation-doped maghemite nanoparticles as functional shell

Human serum albumin (HSA) is a protein found in human blood. Over the last decade, HSA has been evaluated as a promising drug carrier. However, not being magnetic, HSA cannot be used for biomedical applications such as magnetic resonance imaging (MRI) and magnetic drug targeting. Therefore, subseque...

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Bibliographic Details
Published in:Nanotechnology 2015-01, Vol.26 (4), p.1-16
Main Authors: Israel, Liron L, Kovalenko, Elena I, Boyko, Anna A, Sapozhnikov, Alexander M, Rosenberger, Ina, Kreuter, Jorg, Passoni, Lorena, Lellouche, Jean-Paul
Format: Article
Language:English
Subjects:
Construction
Contrast agents
Drugs
Human
Magnetic resonance imaging
Nanoparticles
Nanostructure
Proteins
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Summary:Human serum albumin (HSA) is a protein found in human blood. Over the last decade, HSA has been evaluated as a promising drug carrier. However, not being magnetic, HSA cannot be used for biomedical applications such as magnetic resonance imaging (MRI) and magnetic drug targeting. Therefore, subsequent composites building on iron oxide nanoparticles that are already used clinically as MRI contrast agents are extensively studied. Recently and in this context, innovative fully hydrophilic ultra-small CAN-stabilized maghemite ((CeL sub(n)) super(3/4+)- gamma -Fe sub(2)O sub(3)) nanoparticles have been readily fabricated. The present study discusses the design, fabrication, and characterization of a dual phase hybrid core (rHSA)-shell ((CeL sub(n)) super(3/4+)- gamma -Fe sub(2)O sub(3) NPs) nanosystem. Quite importantly and in contrast to widely used encapsulation strategies, rHSA NP surface-attached (CeL sub(n)) super(3/4+)- gamma -Fe sub(2)O sub(3) NPs enabled to exploit both rHSA (protein functionalities) and (CeL sub(n)) super(3/4+)- gamma -Fe sub(2)O sub(3) NP surface functionalities (COOH and ligand L coordinative exchange) in addition to very effective MRI contrast capability due to optimal accessibility of H sub(2)O molecules with the outer magnetic phase. Resulting hybrid nanoparticles might be used as a platform modular system for therapeutic (drug delivery system) and MR diagnostic purposes.
ISSN:0957-4484
1361-6528
DOI:10.1088/0957-4484/26/4/045601