Microcellular Open Porous Monoliths for Cell Growth by Thiol-Ene Polymerization of Low-Toxicity Monomers in High Internal Phase Emulsions

Open porous microcellular polymers with high degrees of porosity are prepared from divinyl adipate and pentaerythritol tetrakis(3‐mercaptopropionate) by thiol‐ene polymerization within high internal phase emulsions. The influence of monomer ratio, droplet phase volume, and emulsion stirring rate on...

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Bibliographic Details
Published in:Macromolecular bioscience 2015-02, Vol.15 (2), p.253-261
Main Authors: Sušec, Maja, Liska, Robert, Russmüller, Günter, Kotek, Jiři, Krajnc, Peter
Format: Article
Language:English
Subjects:
3-Mercaptopropionic Acid - analogs & derivatives
3-Mercaptopropionic Acid - chemistry
Adipates - chemistry
Alkaline Phosphatase - metabolism
Animals
Biotechnology - methods
Cell growth
Cell Proliferation - physiology
divinyl adipate
Droplets
Emulsion polymerization
Emulsions - chemistry
In vitro testing
Materials Testing
Mice
Microscopy, Electron, Scanning
Monomers
Morphology
Osteoblasts - cytology
polyHIPE
Polymerization
Polymers - chemistry
Porosity
porous polymers
Propylene Glycols - chemistry
Scaffolds
thiol-ene polymerization
tissue engineering
Tissue Scaffolds - chemistry
Toxicity
Vinyl ester resins
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Summary:Open porous microcellular polymers with high degrees of porosity are prepared from divinyl adipate and pentaerythritol tetrakis(3‐mercaptopropionate) by thiol‐ene polymerization within high internal phase emulsions. The influence of monomer ratio, droplet phase volume, and emulsion stirring rate on the morphology and mechanical properties of the products is studied. The newly produced material is successfully applied as a scaffold for osteoblastic MC3T3‐E1 cells in vitro, showing increased rates of cell growth compared to material prepared by standard methods. The combination of high internal phase emulsion templating and thiol‐ene polymerization of vinyl esters and thiols produces highly porous polymers with an interconnected morphology and tunable pore size. The usefulness of novel material is demonstrated by application as a scaffold for in vitro osteoblasts growth.
ISSN:1616-5187
1616-5195
DOI:10.1002/mabi.201400219