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Microcellular Open Porous Monoliths for Cell Growth by Thiol-Ene Polymerization of Low-Toxicity Monomers in High Internal Phase Emulsions
Open porous microcellular polymers with high degrees of porosity are prepared from divinyl adipate and pentaerythritol tetrakis(3‐mercaptopropionate) by thiol‐ene polymerization within high internal phase emulsions. The influence of monomer ratio, droplet phase volume, and emulsion stirring rate on...
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| Published in: | Macromolecular bioscience 2015-02, Vol.15 (2), p.253-261 |
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| container_end_page | 261 |
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| container_title | Macromolecular bioscience |
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| creator | Sušec, Maja Liska, Robert Russmüller, Günter Kotek, Jiři Krajnc, Peter |
| description | Open porous microcellular polymers with high degrees of porosity are prepared from divinyl adipate and pentaerythritol tetrakis(3‐mercaptopropionate) by thiol‐ene polymerization within high internal phase emulsions. The influence of monomer ratio, droplet phase volume, and emulsion stirring rate on the morphology and mechanical properties of the products is studied. The newly produced material is successfully applied as a scaffold for osteoblastic MC3T3‐E1 cells in vitro, showing increased rates of cell growth compared to material prepared by standard methods.
The combination of high internal phase emulsion templating and thiol‐ene polymerization of vinyl esters and thiols produces highly porous polymers with an interconnected morphology and tunable pore size. The usefulness of novel material is demonstrated by application as a scaffold for in vitro osteoblasts growth. |
| doi_str_mv | 10.1002/mabi.201400219 |
| format | article |
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The combination of high internal phase emulsion templating and thiol‐ene polymerization of vinyl esters and thiols produces highly porous polymers with an interconnected morphology and tunable pore size. The usefulness of novel material is demonstrated by application as a scaffold for in vitro osteoblasts growth.</description><identifier>ISSN: 1616-5187</identifier><identifier>EISSN: 1616-5195</identifier><identifier>DOI: 10.1002/mabi.201400219</identifier><identifier>PMID: 25294695</identifier><language>eng</language><publisher>Germany: Blackwell Publishing Ltd</publisher><subject>3-Mercaptopropionic Acid - analogs & derivatives ; 3-Mercaptopropionic Acid - chemistry ; Adipates - chemistry ; Alkaline Phosphatase - metabolism ; Animals ; Biotechnology - methods ; Cell growth ; Cell Proliferation - physiology ; divinyl adipate ; Droplets ; Emulsion polymerization ; Emulsions - chemistry ; In vitro testing ; Materials Testing ; Mice ; Microscopy, Electron, Scanning ; Monomers ; Morphology ; Osteoblasts - cytology ; polyHIPE ; Polymerization ; Polymers - chemistry ; Porosity ; porous polymers ; Propylene Glycols - chemistry ; Scaffolds ; thiol-ene polymerization ; tissue engineering ; Tissue Scaffolds - chemistry ; Toxicity ; Vinyl ester resins</subject><ispartof>Macromolecular bioscience, 2015-02, Vol.15 (2), p.253-261</ispartof><rights>2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5089-8332f356d38bbcba6787b1071c008d6a7b474702dd32c7f3aa130db69cc5f35a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25294695$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sušec, Maja</creatorcontrib><creatorcontrib>Liska, Robert</creatorcontrib><creatorcontrib>Russmüller, Günter</creatorcontrib><creatorcontrib>Kotek, Jiři</creatorcontrib><creatorcontrib>Krajnc, Peter</creatorcontrib><title>Microcellular Open Porous Monoliths for Cell Growth by Thiol-Ene Polymerization of Low-Toxicity Monomers in High Internal Phase Emulsions</title><title>Macromolecular bioscience</title><addtitle>Macromol. Biosci</addtitle><description>Open porous microcellular polymers with high degrees of porosity are prepared from divinyl adipate and pentaerythritol tetrakis(3‐mercaptopropionate) by thiol‐ene polymerization within high internal phase emulsions. The influence of monomer ratio, droplet phase volume, and emulsion stirring rate on the morphology and mechanical properties of the products is studied. The newly produced material is successfully applied as a scaffold for osteoblastic MC3T3‐E1 cells in vitro, showing increased rates of cell growth compared to material prepared by standard methods.
The combination of high internal phase emulsion templating and thiol‐ene polymerization of vinyl esters and thiols produces highly porous polymers with an interconnected morphology and tunable pore size. The usefulness of novel material is demonstrated by application as a scaffold for in vitro osteoblasts growth.</description><subject>3-Mercaptopropionic Acid - analogs & derivatives</subject><subject>3-Mercaptopropionic Acid - chemistry</subject><subject>Adipates - chemistry</subject><subject>Alkaline Phosphatase - metabolism</subject><subject>Animals</subject><subject>Biotechnology - methods</subject><subject>Cell growth</subject><subject>Cell Proliferation - physiology</subject><subject>divinyl adipate</subject><subject>Droplets</subject><subject>Emulsion polymerization</subject><subject>Emulsions - chemistry</subject><subject>In vitro testing</subject><subject>Materials Testing</subject><subject>Mice</subject><subject>Microscopy, Electron, Scanning</subject><subject>Monomers</subject><subject>Morphology</subject><subject>Osteoblasts - cytology</subject><subject>polyHIPE</subject><subject>Polymerization</subject><subject>Polymers - chemistry</subject><subject>Porosity</subject><subject>porous polymers</subject><subject>Propylene Glycols - chemistry</subject><subject>Scaffolds</subject><subject>thiol-ene polymerization</subject><subject>tissue engineering</subject><subject>Tissue Scaffolds - chemistry</subject><subject>Toxicity</subject><subject>Vinyl ester resins</subject><issn>1616-5187</issn><issn>1616-5195</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqNkU9v1DAQxSMEoqVw5YgsceGS4j-xHR_LatmutLvtYQGJi-UkDnFx4sVOtE2_Qb81Dlty4MTJHs3vPc3MS5K3CF4iCPHHVhXmEkOUxQKJZ8k5YoilFAn6fP7n_Cx5FcIdhIjnAr9MzjDFImOCniePW1N6V2prB6s8uDnoDtw674YAtq5z1vRNALXzYBERsPLu2DegGMG-Mc6my05H2o6t9uZB9cZ1wNVg447p3t2b0vTjH5fYDsB04Nr8aMC667XvlAW3jQoaLNvBhigMr5MXtbJBv3l6L5Ivn5f7xXW6uVmtF1ebtKQwF2lOCK4JZRXJi6IsFOM5LxDkqIQwr5jiRcYzDnFVEVzymiiFCKwKJsqSRp0iF8mHk-_Bu1-DDr1sTZgOoDod15aIcS6oEBn9H5QQgeNdI_r-H_TODdOaE8U4IxlHk-G7J2ooWl3Jgzet8qP8m0cExAk4GqvHuY-gnNKWU9pyTlturz6t5ypq05PWhF7fz1rlf8o4J6fy224lFzvylW92SH4nvwESta0C</recordid><startdate>201502</startdate><enddate>201502</enddate><creator>Sušec, Maja</creator><creator>Liska, Robert</creator><creator>Russmüller, Günter</creator><creator>Kotek, Jiři</creator><creator>Krajnc, Peter</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>7U5</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>201502</creationdate><title>Microcellular Open Porous Monoliths for Cell Growth by Thiol-Ene Polymerization of Low-Toxicity Monomers in High Internal Phase Emulsions</title><author>Sušec, Maja ; Liska, Robert ; Russmüller, Günter ; Kotek, Jiři ; Krajnc, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5089-8332f356d38bbcba6787b1071c008d6a7b474702dd32c7f3aa130db69cc5f35a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>3-Mercaptopropionic Acid - analogs & derivatives</topic><topic>3-Mercaptopropionic Acid - chemistry</topic><topic>Adipates - chemistry</topic><topic>Alkaline Phosphatase - metabolism</topic><topic>Animals</topic><topic>Biotechnology - methods</topic><topic>Cell growth</topic><topic>Cell Proliferation - physiology</topic><topic>divinyl adipate</topic><topic>Droplets</topic><topic>Emulsion polymerization</topic><topic>Emulsions - chemistry</topic><topic>In vitro testing</topic><topic>Materials Testing</topic><topic>Mice</topic><topic>Microscopy, Electron, Scanning</topic><topic>Monomers</topic><topic>Morphology</topic><topic>Osteoblasts - cytology</topic><topic>polyHIPE</topic><topic>Polymerization</topic><topic>Polymers - chemistry</topic><topic>Porosity</topic><topic>porous polymers</topic><topic>Propylene Glycols - chemistry</topic><topic>Scaffolds</topic><topic>thiol-ene polymerization</topic><topic>tissue engineering</topic><topic>Tissue Scaffolds - chemistry</topic><topic>Toxicity</topic><topic>Vinyl ester resins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sušec, Maja</creatorcontrib><creatorcontrib>Liska, Robert</creatorcontrib><creatorcontrib>Russmüller, Günter</creatorcontrib><creatorcontrib>Kotek, Jiři</creatorcontrib><creatorcontrib>Krajnc, Peter</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Macromolecular bioscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sušec, Maja</au><au>Liska, Robert</au><au>Russmüller, Günter</au><au>Kotek, Jiři</au><au>Krajnc, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microcellular Open Porous Monoliths for Cell Growth by Thiol-Ene Polymerization of Low-Toxicity Monomers in High Internal Phase Emulsions</atitle><jtitle>Macromolecular bioscience</jtitle><addtitle>Macromol. Biosci</addtitle><date>2015-02</date><risdate>2015</risdate><volume>15</volume><issue>2</issue><spage>253</spage><epage>261</epage><pages>253-261</pages><issn>1616-5187</issn><eissn>1616-5195</eissn><abstract>Open porous microcellular polymers with high degrees of porosity are prepared from divinyl adipate and pentaerythritol tetrakis(3‐mercaptopropionate) by thiol‐ene polymerization within high internal phase emulsions. The influence of monomer ratio, droplet phase volume, and emulsion stirring rate on the morphology and mechanical properties of the products is studied. The newly produced material is successfully applied as a scaffold for osteoblastic MC3T3‐E1 cells in vitro, showing increased rates of cell growth compared to material prepared by standard methods.
The combination of high internal phase emulsion templating and thiol‐ene polymerization of vinyl esters and thiols produces highly porous polymers with an interconnected morphology and tunable pore size. The usefulness of novel material is demonstrated by application as a scaffold for in vitro osteoblasts growth.</abstract><cop>Germany</cop><pub>Blackwell Publishing Ltd</pub><pmid>25294695</pmid><doi>10.1002/mabi.201400219</doi><tpages>9</tpages></addata></record> |
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| subjects | 3-Mercaptopropionic Acid - analogs & derivatives 3-Mercaptopropionic Acid - chemistry Adipates - chemistry Alkaline Phosphatase - metabolism Animals Biotechnology - methods Cell growth Cell Proliferation - physiology divinyl adipate Droplets Emulsion polymerization Emulsions - chemistry In vitro testing Materials Testing Mice Microscopy, Electron, Scanning Monomers Morphology Osteoblasts - cytology polyHIPE Polymerization Polymers - chemistry Porosity porous polymers Propylene Glycols - chemistry Scaffolds thiol-ene polymerization tissue engineering Tissue Scaffolds - chemistry Toxicity Vinyl ester resins |
| title | Microcellular Open Porous Monoliths for Cell Growth by Thiol-Ene Polymerization of Low-Toxicity Monomers in High Internal Phase Emulsions |
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