Preparation of a New Radiolabeled Biomaterial and Its Biodistribution in Mice

• Published in: Journal of bionics engineering 2013-10, Vol.10 (4), p.514-521
• Main Authors: Ma, Jinshu, Liu, Zhenning, Wang, Fang, Zhou, Qinghai, Feng, Chao, Li, Fan
• Format: Article
• Language: English
• Subjects: Artificial Intelligence; Biochemical Engineering; Biocompatibility; biodistribution; Bioinformatics; biomaterial; Biomaterials; Biomedical Engineering and Bioengineering; Biomedical Engineering/Biotechnology; Biomedical materials; Bones; Carbon dioxide; Engineering; Mice; poly-propylene carbonate; PPC; Surgical implants; Toxicity; 体内; 制备; 小鼠; 放射性标记; 炎症反应; 生物材料; 生物相容性; 聚碳酸亚丙酯
• ISSN: 1672-6529; 2543-2141
• DOI: 10.1016/S1672-6529(13)60245-0

Biomaterials have attracted more attention from biomedical research in recent years. Yet there are still unmet demands for current biomaterials, such as the reduction of local inflammation of the implantation site. Poly-Propylene Carbonate （PPC）, a polymer with ester bonds on COz backbone, degrades to CO2 and water, which are natural components of human body, yielding less inflammatory response than traditional biomaterials. However, the tensile strength and heat resistance properties of PPC are less ideal. In order to improve the properties of PPC, we have developed a new PPC （M-PPC）, modified by mixing with Poly-3-Hydroxybutyrate （PHB）. Here, we report the biodistribution profiles of PPC and M-PPC, their biocompatibility and toxicity. 125I-radiolabeled PPC and M-PPC were prepared and their biodistribution in Balb/c mice were investigated. Then acute systemic toxicity and haemolysis assays were conducted to study their toxicity and biocompatibility respectively. Results show that M-PPC has a good potential to be used as bone repair materials because it possesses typical biodistribution pattern in major organs, minimal toxicity and good biocompatibility.